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雑誌文献

耳鼻咽喉科・頭頸部外科91巻6号

2019年05月発行

特集 細菌感染に立ち向かう—抗菌薬使用の新常識

《細菌感染に関する新たな知見》

腸内細菌に関する最近の話題と糞便微生物移植法

著者: 水野慎大1 金井隆典1

所属機関: 1慶應義塾大学医学部内科学(消化器)

ページ範囲:P.467 - P.471

文献概要

POINT

●腸内細菌が攪乱されたdysbiosisは全身疾患の発症と関わっている。

●糞便微生物移植法(FMT)はdysbiosisの改善を強力に誘導する治療法である。

●FMTは多数の全身疾患の治療法として期待されている。

●安全面・有効性のいずれにおいてもFMTは発展途上の治療法である。

参考文献

1)Chua HH, et al:Intestinal dysbiosis featuring abundance of ruminococcus gnavus associates with allergic diseases in infants. Gastroenterology 154:154-167, 2018
2)Kiyohara H, et al:Toll-like receptor 7 agonist-induced dermatitis causes severe dextran sulfate sodium colitis by altering the gut microbiome and immune cells. Cell Mol Gastroenterol Hepatol 7:135-156, 2018
3)Eiseman B, et al:Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery 44:854-859, 1958
4)Van Nood E, et al:Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 368:407-415, 2013
5)Lessa FC, et al:Burden of Clostridium difficile infection in the United States. N Engl J Med 372:825-834, 2015
6)Bakken JS, et al:Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol 9:1044-1049, 2011
7)Mullish BH, et al:The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications:joint British Society of Gastroenterology(BSG)and Healthcare Infection Society(HIS)guidelines. Gut 67:1920-1941, 2018
8)Mizuno S, et al:Single fecal microbiota transplantation failed to change intestinal microbiota and had limited effectiveness against ulcerative colitis in Japanese patients. Intest Res 15:68-74, 2017
9)Paramsothy S, et al:Multidonor intensive faecal microbiota transplantation for active ulcerative colitis:a randomised placebo-controlled trial. Lancet 389:1218-1228, 2017
10)Johnsen PH, et al:Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome:a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial. Lancet Gastroenterol Hepatol 3:17-24, 2018
11)Halkjær SI, et al:Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome:results from a randomised, double-blind placebo-controlled study. Gut 67:2107-2115, 2018
12)Ridaura VK, et al:Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214, 2013
13)Vrieze A, et al:Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143:913-916, 2012
14)Kang DW, et al:Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms:an open-label study. Microbiome 5:10, 2017
15)Qi X, et al:Treating steroid refractory intestinal acute graft-vs. -host disease with fecal microbiota transplantation:a pilot study. Front Immunol 9:2195, 2018
16)Kao D, et al:Effect of oral capsule- vs colonoscopy-delivered fecal microbiota transplantation on recurrent clostridium difficile infection:a randomized clinical trial. JAMA 318:1985-1993, 2017
17)Moayyedi P, et al:Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 149:102-109, 2015
18)Smillie CS, et al:Strain tracking reveals the determinants of bacterial engraftment in the human gut following fecal microbiota transplantation. Cell Host Microbe 23:229-240, 2018
19)Mizuno S, et al:Bifidobacterium-rich fecal donor may be a positive predictor for successful fecal microbiota transplantation in patients with irritable bowel syndrome. Digestion 96:29-38, 2017
20)Ott SJ, et al:Efficacy of sterile fecal filtrate transfer for treating patients with clostridium difficile infection. Gastroenterology 152:799-811, 2017
21)McDonald JAK, et al:Inhibiting growth of clostridioides difficile by restoring valerate, produced by the intestinal microbiota. Gastroenterology 155:1495-1507, 2018

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1316

印刷版ISSN:0914-3491

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