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耳鼻咽喉科・頭頸部外科92巻12号

2020年11月発行

文献概要

特集 漢方医学入門—耳鼻咽喉科で漢方薬を使いこなす 《私の推奨—代表的な漢方薬の使い方》

半夏瀉心湯と黄連湯を頭頸部癌への化学放射線療法による粘膜障害に用いる

著者: グンデゥズメーメット1 保富宗城1

所属機関: 1和歌山県立医科大学耳鼻咽喉科・頭頸部外科学講座

ページ範囲:P.1004 - P.1009

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●口腔内有害事象の重症度分類について説明する。

●化学放射線治療後の口内炎に対しては,適切な評価と漢方薬治療を行う。

●口内炎治療に使用する半夏瀉心湯と黄連湯の機能・機序,応用方法を理解する。

参考文献

1)Russo G, et al:Radiation treatment breaks and ulcerative mucositis in head and neck cancer. Oncologist 13:886-898, 2008
2)Bese NS, et al:Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumor sites and practical methods for compensation. Int J Radiat Oncol Biol Phys 68:654-661, 2007
3)Sonis ST:Oral mucositis. Anticancer Drugs 22:607-612, 2011
4)Maria OM, et al:Radiation-induced oral mucositis. Front Oncol 7:89, 2017
5)Kusiak A, et al:Oncological-therapy related oral mucositis as an interdisciplinary problem-literature review. Int J Environ Res Public Health 17:2464, 2020
6)上野尚雄:口腔粘膜炎の予防と治療.薬事61:1420-1425,2019
7)Kono T, et al:Topical application of hangeshashinto(TJ-14)in the treatment of chemotherapy-induced oral mucositis. World J Oncol 1:232-235, 2010
8)Matsuda C, et al:Double-blind, placebo-controlled, randomized phase Ⅱ study of TJ-14(Hangeshashinto)for infusional fluorinated-pyrimidine-based colorectal cancer chemotherapy-induced oral mucositis. Cancer Chemother Pharmacol 76:97-103, 2015
9)Nishikawa K, et al:The clinical impact of Hangeshashinto(TJ-14)in the treatment of chemotherapy-induced oral mucositis in gastric cancer and colorectal cancer:Analyses of pooled data from two phase Ⅱ randomized clinical trials(HANGESHA-G and HANGESHA-C). J Cancer 9:1725-1730, 2018
10)Aoyama T, et al:Double-blind, placebo-controlled, randomized phase Ⅱ study of TJ-14(hangeshashinto)for gastric cancer chemotherapy-induced oral mucositis. Cancer Chemother Pharmacol 73:1047-1054, 2014
11)Yamashita T, et al:A traditional Japanese medicine—Hangeshashinto(TJ-14)—alleviates chemoradiation-induced mucositis and improves rates of treatment completion. Support Care Cancer 23:29-35, 2015
12)吉田直久・他:抗がん剤に伴う口腔粘膜炎に対する半夏瀉心湯の口腔内浸透法の効果—口内炎に対する半夏瀉心湯の有用性.Prag Med 37:1339-1343,2017
13)Kindgen-Milles D:Effects of prostaglandin E2 on the intensity of bradykinin-evoked pain from skin and veins of humans. Eur J Pharmacol 294:491-496, 1995
14)Lalla RV, et al:Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis:a pilot study. Support Care Cancer 18:95-103, 2010
15)Kono T, et al:Multitargeted effects of hangeshashinto for treatment of chemotherapy-induced oral mucositis on inducible prostaglandin E2 production in human oral keratinocytes. Integr Cancer Ther 13:435-445, 2014
16)Nievergelt A, et al:Ginger phenylpropanoids inhibit IL-1beta and prostanoid secretion and disrupt arachidonate-phospholipid remodeling by targeting phospholipases A2. J Immunol 187:4140-4150, 2011
17)Nurtjahja-Tjendraputra E, et al:Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res 111:259-265, 2003
18)van Breemen RB, et al:Cyclooxygenase-2 inhibitors in ginger(Zingiber officinale). Fitoterapia 82:38-43, 2011
19)Lantz RC, et al:The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine 14:123-128, 2007
20)宮野加奈子・他:抗がん剤治療による口内炎に対する半夏瀉心湯の効果—明日の口内炎患者のために.日薬理誌146:76-80,2015
21)Matsumoto C, et al:Analysis of the antioxidative function of the radioprotective Japanese traditional(Kampo)medicine, hangeshashinto, in an aqueous phase. J Radiat Res 56:669-677, 2015
22)Fukamachi H, et al:Effects of Hangeshashinto on growth of oral microorganisms. Evid Based Complement Alternat Med 2015:512947, 2015
23)Hiroshima Y, et al:Effect of Hangeshashinto on calprotectin expression in human oral epithelial cells. Odontology 104:152-162, 2016
24)Hitomi S, et al:The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model. Arch Oral Biol 66:30-37, 2016
Channels. Pharmacol Res 117:288-302, 2017
26)宮野加奈子・他:がん薬物療法の副作用に対する漢方薬の考え方と使い方.口内炎.薬局69:221-226,2018
27)Sunagawa M, et al:Kampo(Traditional Japanese herbal)formulae for treatment of stomatitis and oral mucositis. Medicines(Basel) 5:130, 2018
28)Ara T, et al:Preventive effects of a kampo medicine, orento on inflammatory responses in lipopolysaccharide treated human gingival fibroblasts. Biol Pharm Bull 33:611-616, 2010
29)坂口直哉:日常診療で使える漢方(実践編):口内炎・よだれ皮膚炎.小児診療81:179-181,2018
30)稲葉博司:口内炎の漢方治療.MB ENT 199:61-68,2016
31)王 宝禮:口腔疾患への立効散,排膿散及湯,白虎加人参湯,五苓散,半夏瀉心湯,菌陳蒿湯,黄連湯を用いた薬物療法.歯薬物療33:32-44,2014
32)岡 進:口内炎に対する黄連湯の効果.Pharm Med 25:35-38,2007
33)河野 透:病棟でよく使う漢方薬.半夏瀉心湯.薬事60:453-460,2018
34)Bockel S, et al:Pharmacological modulation of radiation-induced oral mucosal complications. Cancer Radiother 22:429-437, 2018
35)仲江川雄太・他:化学放射線療法による口内炎への内服・外用薬の使い方.MB ENT 231:109-113,2019
36)De Sanctis V, et al:Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies:Literature review and consensus statements. Crit Rev Oncol Hematol 100:147-166, 2016
37)三嶋秀行・他:抗がん剤による口内炎に対する漢方薬.Mebio 33:26-30,2016
38)宮野加奈子・他:抗がん剤の副作用軽減に貢献する漢方薬—基礎エビデンスの最前線.Mebio 33:10-17,2016

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1316

印刷版ISSN:0914-3491

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