耳鼻咽喉科・頭頸部外科93巻7号

2021年06月発行

特集 必見！頭頸部がんのあたらしい治療 《あたらしい放射線治療》

粒子線治療

著者： 小藤昌志¹

所属機関： ¹国立研究開発法人量子科学技術研究開発機構 放射線医学総合研究所重粒子線治療研究部

ページ範囲：P.510 - P.515

POINT

●粒子線治療（重粒子線治療・陽子線治療）はX線治療と比較して線量集中性に優れる。

●重粒子線治療はX線治療と殺細胞作用が異なるため，X線抵抗性腫瘍にも効果が期待できる。

●粒子線治療は頭頸部悪性腫瘍（口腔・咽喉頭の扁平上皮癌を除く）に保険適用となっている。

参考文献

1）Patel SH, et al：Charged particle therapy versus photon therapy for paranasal sinus and nasal cavity malignant diseases：a systematic review and meta-analysis. Lancet Oncol 15：1027-1038, 2014

2）日本放射線腫瘍学会：保険診療として実施する粒子線治療（陽子線治療，重粒子線治療）において推奨される疾患別治療方法　https://www.jastro.or.jp/medicalpersonnel/particle_beam/2018/03/post-10.html

3）小藤昌志・他：肉腫を除く頭頸部悪性腫瘍に対する重粒子線治療の多施設共同後向き観察研究（J-CROS 1402 HN）．頭頸部癌43：362-366，2017

4）Koto M, et al：Multicenter study of carbon-ion radiation therapy for mucosal melanoma of the head and neck：subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group（J-CROS）study（1402 HN）. Int J Radiat Oncol Biol Phys 97：1054-1060, 2017

5）Sulaiman NS, et al：Multicenter study of carbon-ion radiation therapy for adenoid cystic carcinoma of the head and neck：subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group（J-CROS）study（1402 HN）. Int J Radiat Oncol Biol Phys 100：639-646, 2018

6）Saitoh JI, et al：A multicenter study of carbon-ion radiation therapy for head and neck adenocarcinoma. Int J Radiat Oncol Biol Phys 99：442-449, 2017

7）Shirai K, et al：Multi-institutional retrospective study of mucoepidermoid carcinoma treated with carbon-ion radiotherapy. Cancer Sci 108：1447-1451, 2017

8）Suefuji H, et al：A retrospective multicenter study of carbon ion radiotherapy for locally advanced olfactory neuroblastomas. Anticancer Res 38：1665-1670, 2018

9）Koto M, et al：Definitive carbon-ion radiation therapy for locally advanced sinonasal malignant tumors：subgroup analysis of a multicenter study by the Japan Carbon-Ion Radiation Oncology Study Group（J-CROS）. Int J Radiat Oncol Biol Phys 102：353-361, 2018

10）Ikawa H, et al：Multicenter study of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity. Cancer Med 8：5482-5491, 2019

11）Hayashi K, et al：A retrospective multicenter study of carbon-ion radiotherapy for major salivary gland carcinomas：subanalysis of J-CROS 1402 HN. Cancer Sci 109：1576-1582, 2018

12）Abe T, et al：A multi-institutional retrospective study of carbon-ion radiotherapy for non-squamous cell malignant tumors of the nasopharynx：subanalysis of Japan Carbon-Ion Radiation Oncology Study Group study 1402 HN. Cancer Med 7：6077-6083, 2018

13）Hayashi K, et al：A retrospective multicenter study of carbon-ion radiotherapy for external auditory canal and middle ear carcinomas. Cancer Med 8：51-57, 2019

14）Zenda S, et al：Phase Ⅱ study of proton beam therapy as a nonsurgical approach for mucosal melanoma of the nasal cavity or para-nasal sinuses. Radiother Oncol 118：267-271, 2016

15）Nakamura N, et al：Proton beam therapy for olfactory neuroblastoma. Radiother Oncol 122：368-372, 2017

16）Koto M, et al：Risk factors for brain injury after carbon ion radiotherapy for skull base tumors. Radiother Oncol 111：25-29, 2014

17）Bhattacharyya T, et al：Assessment of risk factors associated with development of oronasal fistula as a late complication after carbon-ion radiotherapy for head and neck cancer. Radiother Oncol 144：53-58, 2020

18）Hasegawa A, et al：Outcomes of visual acuity in carbon ion radiotherapy：analysis of dose-volume histograms and prognostic factors. Int J Radiat Oncol Biol Phys 64：396-401, 2006

19）Shirai K, et al：Dose-volume histogram analysis of brainstem necrosis in head and neck tumors treated using carbon-ion radiotherapy. Radiother Oncol 125：36-40, 2017

20）Zenda S, et al：Late toxicity of proton beam therapy for patients with the nasal cavity, para-nasal sinuses, or involving the skull base malignancy：importance of long-term follow-up. Int J Clin Oncol 20：447-454, 2015