耳鼻咽喉科・頭頸部外科94巻1号

2022年01月発行

Review Article

頭頸部がんの基礎研究

著者： 峯田周幸¹

所属機関： ¹浜松医科大学

ページ範囲：P.78 - P.92

文献概要

Summary

●これまで，頭頸部がんに特徴的にみられる遺伝子の欠失や変異，あるいはコピー数の増幅などが多数指摘されており，近年は各遺伝子のネットワーク，染色体異常，エピジェネティクス，プロテオミクスなどの研究が進んでいる。

●本稿では，次世代シークエンスによるゲノム解析で明らかになったこと，また頭頸部がんと血管内皮増殖因子（VEGF），ヒトパピローマウイルス（HPV），がん幹細胞などとの関連について解説し，創薬や治療法の進歩に対する期待に関しても述べる。

●ニボルマブの登場によりあらたながん治療法も一気に広まった。

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