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文献概要
増刊号 結果の読み方がよくわかる! 耳鼻咽喉科検査ガイド Ⅵ.頭頸部腫瘍の検査
免疫染色
著者: 村瀬貴幸1 稲垣宏1
所属機関: 1名古屋市立大学大学院医学研究科臨床病態病理学
ページ範囲:P.204 - P.212
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◆2017年のWHO分類により,顎口腔領域,鼻咽頭領域,唾液腺における腫瘍組織型が整理されたが,各組織型の鑑別には免疫染色や遺伝子解析が重要視されている.
◆唾液腺腫瘍では組織型に特異的な遺伝子異常が明らかにされ,遺伝子解析が病理診断において必要となっているが,大学を除いた市中総合病院では検査体制の確立は難しい状況である.
◆唾液腺腫瘍では組織型に特異性の高い免疫染色用の抗体も開発されつつあり,市中総合病院の病理検査室においても検索可能になっていくものと考えられる.
◆2017年のWHO分類により,顎口腔領域,鼻咽頭領域,唾液腺における腫瘍組織型が整理されたが,各組織型の鑑別には免疫染色や遺伝子解析が重要視されている.
◆唾液腺腫瘍では組織型に特異的な遺伝子異常が明らかにされ,遺伝子解析が病理診断において必要となっているが,大学を除いた市中総合病院では検査体制の確立は難しい状況である.
◆唾液腺腫瘍では組織型に特異性の高い免疫染色用の抗体も開発されつつあり,市中総合病院の病理検査室においても検索可能になっていくものと考えられる.
参考文献
1)El-Naggar AK, et al(eds):WHO classification of head and neck tumours, 4th ed. IARC press, Lyon, 2017, pp203-260(Odontogenic and maxillofacial bone tumours)
2)El-Naggar AK, et al(eds):WHO classification of head and neck tumours, 4th ed. IARC press, Lyon, 2017, pp11-62(Tumours of the nasal cavity, paranasal sinuses and skull base)
3)El-Naggar AK, et al(eds):WHO classification of head and neck tumours, 4th ed. IARC press, Lyon, 2017, pp63-76(Tumours of the nasopharynx)
4)El-Naggar AK, et al(eds):WHO classification of head and neck tumours, 4th ed. IARC press, Lyon, 2017, pp159-202(Tumours of salivary glands)
5)Meyer MT, et al:2021 update on diagnostic markers and translocation in salivary gland tumors. Int J Mol Sci 22:6771, 2021
6)Reinheimer A, et al:Retrospective study of 124 cases of salivary gland tumors and literature review. J Clin Exp Dent 11:e1025-e1032, 2019
7)Gontarz M, et al:Epidemiology of primary epithelial salivary gland tumors in southern Poland—A 26-year, clinicopathologic, retrospective analysis. J Clin Med 10:1663, 2021
8)Zhu S, et al:Review and updates of immunohistochemistry in selected salivary gland and head and neck tumors. Arch Pathol Lab Med 139:55-66, 2015
9)Speight PM, et al:Salivary gland tumours:diagnostic challenges and an update on the latest WHO classification. Diagn Histopathol 26:147-158, 2020
10)Shah AA, et al:EWSR1 genetic rearrangements in salivary gland tumors:a specific and very common feature of hyalinizing clear cell carcinoma. Am J Surg Pathol 37:571-578, 2013
11)Skaugen JM, et al:Evaluation of NR4A3 immunohistochemistry(IHC)and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma. Cancer Cytopathol 129:104-113, 2021
12)Skálová A, et al:Expanding the molecular spectrum of secretory carcinoma of salivary glands with a novel VIM-RET fusion. Am J Surg Pathol 44:1295-1307, 2020
13)Katabi N, et al:Consistent PLAG1 and HMGA2 abnormalities distinguish carcinoma ex-pleomorphic adenoma from its de novo counterparts. Hum Pathol 46:26-33, 2015
14)Andreasen S, et al:Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma. Acta Ophthalmol 96:e768-e771, 2018
15)Moutasim KA, et al:Salivary gland tumours:update on molecular diagnostics. Diagn Histopathol 26:159-164, 2020
16)Persson M, et al:Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci U S A 106:18740-18744, 2009
17)North JP, et al:Detection of MYB alterations and other immunohistochemical markers in primary cutaneous adenoid cystic carcinoma. Am J Surg Pathol 39:1347-1356, 2015
18)Fujii K, et al:MYB, MYBL1, MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinoma. Histopathology 71:823-834, 2017
19)Šteiner P, et al:Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands. Virchows Arch 473:471-480, 2018
20)Brill LB 2nd, et al:Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol 24:1169-1176, 2011
21)West RB, et al:MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation. Am J Surg Pathol 35:92-99, 2011
hybridization in salivary rare basaloid lesions. Front Oncol 10:870, 2020
23)Haller F, et al:Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands. Nat Commun 10:368, 2019
24)Owosho A, et al:NR4A3(NOR-1)immunostaining shows better performance than DOG1 immunostaining in acinic cell carcinoma of salivary gland:a preliminary study. J Oral Maxillofac Res 12:e4, 2021
25)Xu B, et al:Pan-Trk immunohistochemistry is a sensitive and specific ancillary tool for diagnosing secretory carcinoma of the salivary gland and detecting ETV6-NTRK3 fusion. Histopathology 76:375-382, 2020
26)Bell D, et al:Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland. Virchows Arch 476:295-305, 2020
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