文献詳細
増刊号 結果の読み方がよくわかる! 耳鼻咽喉科検査ガイド
Ⅵ.頭頸部腫瘍の検査
文献概要
POINT
◆唾液腺腫瘍では,多くの腫瘍型に特異的な融合遺伝子がみられる.
◆融合遺伝子の検出は非常に有用だが,実施できる施設は限られている.
◆RT-PCR法やFISH法を用いた解析が行われ,それぞれ長所・短所がある.
◆唾液腺腫瘍では,多くの腫瘍型に特異的な融合遺伝子がみられる.
◆融合遺伝子の検出は非常に有用だが,実施できる施設は限られている.
◆RT-PCR法やFISH法を用いた解析が行われ,それぞれ長所・短所がある.
参考文献
1)Urano M, et al:Diagnostic significance of HRAS mutations in epithelial-myoepithelial carcinomas exhibiting a broad histopathologic spectrum. Am J Surg Pathol 43:984-994, 2019
2)Skálová A, et al:Fusion-positive salivary gland carcinomas. Genes Chromosomes Cancer, 2022(In press)
3)Mertens F, et al:The emerging complexity of gene fusions in cancer. Nat Rev Cancer 15:371-381, 2015
4)Toper MH, et al:Molecular pathology of salivary gland neoplasms:diagnostic, prognostic, and predictive perspective. Adv Anat Pathol 28:81-93, 2021
5)Nakano S, et al:Salivary mucoepidermoid carcinoma:histological variants, grading systems, CRTC1/3-MAML2 fusions, and clinicopathological features. Histopathology, 80:729-735, 2022.
6)Togashi Y, et al:MYB and MYBL1 in adenoid cystic carcinoma:diversity in the mode of genomic rearrangement and transcripts. Mod Pathol 31:934-946, 2018
7)Haller F, et al:Nuclear NR4A3 immunostaining is a specific and sensitive novel marker for acinic cell carcinoma of the salivary glands. Am J Surg Pathol 43:1264-1272, 2019
8)Bishop JA, et al:Oncocytic intraductal carcinoma of salivary glands:a distinct variant with TRIM33-RET fusions and BRAF V600E mutations. Histopathology 79:338-346, 2021
9)Skálová A, et al:Expanding the molecular spectrum of secretory carcinoma of salivary glands with a novel VIM-RET fusion. Am J Surg Pathol 44:1295-1307, 2020
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