icon fsr

文献詳細

雑誌文献

耳鼻咽喉科・頭頸部外科96巻11号

2024年10月発行

特集 頭頸部がん薬物療法—プロに学ぶ最善の選択

《扁平上皮癌に対する薬物療法》

切除不能/再発・転移頭頸部がんに対する治療:殺細胞性抗がん薬を中心に

著者: 山﨑知子1

所属機関: 1埼玉医科大学国際医療センター頭頸部腫瘍科

ページ範囲:P.924 - P.928

文献概要

POINT

●頭頸部がんで承認されている薬剤として,殺細胞性抗がん薬ではプラチナ系,フッ化ピリミジン系,タキサン系が,分子標的薬ではEGFR阻害薬であるセツキシマブが,免疫チェックポイント阻害薬では抗PD-1抗体薬であるニボルマブ,ペムブロリズマブが挙げられる。本稿では,殺細胞性抗がん薬を中心にまとめた。

参考文献

1)Kowalski LP, et al:Natural history of untreated head and neck cancer. Eur J Cancer 36:1032-7, 2000
2)Burtness B, et al:Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck(KEYNOTE-048):a randomised, open-label, phase 3 study. Lancet 394:1915-1928, 2019
3)Ferris RL, et al:Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck. N Engl J Med 375:1856-1867, 2016
4)Armand JP, et al:Chemotherapy in head and neck cancer. Eur J Cancer 31A:819-822, 1995
5)Morton RP, et al:Cisplatinum and bleomycin for advanced or recurrent squamous cell carcinoma of the head and neck:a randomised factorial phase Ⅲ controlled trial. Cancer Chemother Pharmacol 15:283-289, 1985
6)Grose WE, et al:Comparison of methotrexate and cisplatin for patients with advanced squamous cell carcinoma of the head and neck region:a Southwest Oncology Group Study. Cancer Treat Rep 69:577-581, 1985
7)Forastiere AA, et al:Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck:a Southwest Oncology Group study. J Clin Oncol 10:1245-1251, 1992
8)Jacobs C, et al:A phase Ⅲ randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck. J Clin Oncol 10:257-263, 1992
9)Sacco AG, et al:Current Treatment Options for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma. J Clin Oncol 33:3305-3313, 2015
10)Vermorken JB, et al:Platinum-Based Chemotherapy plus Cetuximab in Head and Neck Cancer. N Engl J Med 359:1116-1127, 2008
11)Mesía R, et al:Quality of life of patients receiving platinum-based chemotherapy plus cetuximab first line for recurrent and/or metastatic squamous cell carcinoma of the head and neck. Ann Oncol 21:1967-1973, 2010
12)Yoshino T, et al:Platinum-based chemotherapy plus cetuximab for the first-line treatment of Japanese patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck:results of a phase Ⅱ trial. Jpn J Clin Oncol 43:524-531, 2013
13)Guigay J, et al:Cetuximab, docetaxel, and cisplatin versus platinum, fluorouracil, and cetuximab as first-line treatment in patients with recurrent or metastatic head and neck squamous-cell carcinoma(GORTEC 2014-01 TPExtreme):a multicentre, open-label, randomised, phase 2 trial. Lancet Oncol 22:463-475, 2021
14)Tahara M, et al:Phase Ⅱ trial of combination treatment with paclitaxel, carboplatin and cetuximab(PCE)as first-line treatment in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck(CSPOR-HN02). Ann Oncol 29:1004-1009, 2018
15)Vermorken JB, et al:Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck(SPECTRUM):an open-label phase 3 randomised trial. Lancet Oncol 14:697-710, 2013
16)Hitt R, et al:Phase Ⅱ study of the combination of cetuximab and weekly paclitaxel in the first-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of head and neck. Ann Oncol 23:1016-1022, 2012
17)Rubió-Casadevall J, et al:TTCC-2019-02:real-world evidence of first-line cetuximab plus paclitaxel in recurrent or metastatic squamous cell carcinoma of the head and neck. Front Oncol 13:1226939, 2023
18)Del Barco Morillo E, et al:Phase Ⅱ study of panitumumab and paclitaxel as first-line treatment in recurrent or metastatic head and neck cancer. TTCC-2009-03/VECTITAX study. Oral Oncol 62:54-59, 2016
19)Lin JT, et al:Chemotherapy with modified docetaxel, cisplatin, and 5-fluorouracil in patients with metastatic head and neck cancer. Adv Ther 29:71-77, 2012
20)Cho H, et al:Docetaxel, cisplatin, and fluorouracil for patients with inoperable recurrent or metastatic head and neck squamous cell carcinoma. Auris Nasus Larynx 42:396-400, 2015
21)Szturz P, et al:Management of recurrent and metastatic oral cavity cancer:Raising the bar a step higher. Oral Oncol 101:104492, 2020
22)Machiels JP, et al:Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy(LUX-Head & Neck 1):an open-label, randomised phase 3 trial. Lancet Oncol 16:583-594, 2015
23)Markman M, et al:Second-line platinum therapy in patients with ovarian cancer previously treated with cisplatin. J Clin Oncol 9:389-393, 1991
24)Seiwert TY, et al:A randomized, phase Ⅱ study of afatinib versus cetuximab in metastatic or recurrent squamous cell carcinoma of the head and neck. Ann Oncol 25:1813-1820, 2014
25)犬山征夫:進行・再発頭頸部癌患者に対するS-1の後期臨床第Ⅱ相試験—多施設共同研究.癌と化療28:1381-1390,2001
26)犬山征夫:頭頸部癌に対するCisplatinのphase Ⅱ study.癌と化療13:232-238,1986
27)Vermorken JB, et al:Open-label, uncontrolled, multicenter phase Ⅱ study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J Clin Oncol 25:2171-2177, 2007

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1316

印刷版ISSN:0914-3491

雑誌購入ページに移動
icon up

本サービスは医療関係者に向けた情報提供を目的としております。
一般の方に対する情報提供を目的としたものではない事をご了承ください。
また,本サービスのご利用にあたっては,利用規約およびプライバシーポリシーへの同意が必要です。

※本サービスを使わずにご契約中の電子商品をご利用したい場合はこちら