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耳鼻咽喉科・頭頸部外科96巻4号

2024年04月発行

文献概要

特集 頭頸部がん診療のControversy 化学放射線療法 どっちを選ぶ? Triweekly CDDP-CRT vs Weekly CDDP-CRT

Weekly CDDP-CRT

著者: 浜田誠二郎1 加納里志1

所属機関: 1北海道大学大学院医学研究院耳鼻咽喉科・頭頸部外科学教室

ページ範囲:P.330 - P.333

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●術後化学放射線療法(CRT)においては,JCOG1008試験にて,weekly CDDP-CRT(シスプラチン40mg/m2)がtriweekly CDDP-CRT(100mg/m2)に対して非劣性であることが証明された。

●初回治療においても,weekly CDDP-CRTがtriweekly CDDP-CRTと比較して非劣性であると報告されている。

●高齢者に関しては,有害事象によりtriweekly CDDP-CRTの実施・完遂が困難である可能性があり,weekly CDDP-CRTでの検証が望まれる。

参考文献

1)Browman GP, et al:Choosing a concomitant chemotherapy and radiotherapy regimen for squamous cell head and neck cancer:a systematic review of the published literature with subgroup analysis. Head Neck 23:579-589, 2001
2)Forastiere AA, et al:Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 349:2091-2098, 2003
3)Marcial VA, et al:Concomitant cisplatin chemotherapy and radiotherapy in advanced mucosal squamous cell carcinoma of the head and neck. Long-term results of the Radiation Therapy Oncology Group Study 81-17. Cancer 66:1861-1868, 1990
4)Al-Sarraf M, et al:Concurrent radiotherapy and chemotherapy with cisplatin in inoperable squamous cell carcinoma of the head and neck. An RTOG Study. Cancer 59:259-265, 1987
5)Strojan P, et al:Cumulative cisplatin dose in concurrent chemoradiotherapy for head and neck cancer:a systematic review. Head Neck(Suppl 1) 38:E2151-E2158, 2016
6)Bahl M, et al:Tolerability of the Intergroup 0099(INT 0099)regimen in locally advanced nasopharyngeal cancer with a focus on patients' nutritional status. Int J Radiat Oncol Biol Phys 60:1127-1136, 2004
7)Huguenin P, et al:Concomitant cisplatin significantly improves locoregional control in advanced head and neck cancers treated with hyperfractionated radiotherapy. J Clin Oncol 22:4665-4673, 2004
8)Wee J, et al:Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage Ⅲ and Ⅳ nasopharyngeal cancer of the endemic variety. J Clin Oncol 23:6730-6738, 2005
9)Jeremic B, et al:Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck:a prospective randomized trial. J Clin Oncol 18:1458-1464, 2000
10)Chan AT, et al:Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst 97:536-539, 2005
11)Homma A, et al:Concomitant weekly cisplatin and radiotherapy for head and neck cancer. Jpn J Clin Oncol 41:980-986, 2011
12)Noronha V, et al:Once-a-week versus once-every-3-weeks cisplatin chemoradiation for locally advanced head and neck cancer:a phase Ⅲ randomized noninferiority trial. J Clin Oncol 36:1064-1072, 2018
13)Kiyota N, et al:Weekly cisplatin plus radiation for postoperative head and neck cancer(JCOG1008):a multicenter, noninferiority, phase Ⅱ/Ⅲ randomized controlled trial. J Clin Oncol 40:1980-1990, 2022
14)Mohamed A, et al:Concurrent chemoradiotherapy with weekly versus triweekly cisplatin in locally advanced squamous cell carcinoma of the head and neck:comparative analysis. Head Neck 41:1490-1498, 2019
15)Sharma A, et al:An open-label, noninferiority phase Ⅲ RCT of weekly versus three weekly cisplatin and radical radiotherapy in locally advanced head and neck squamous cell carcinoma(ConCERT trial). J Clin Oncol 40(16_suppl):6004, 2022
16)Wolf GT, et al:Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 324:1685-1690, 1991
17)Lefebvre JL, et al:Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma:10-year results of EORTC trial 24891. Ann Oncol 23:2708-2714, 2012
18)Mizumachi T, et al:Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with concurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell carcinoma. Int J Clin Oncol 20:431-437, 2015
19)Lacas B, et al:Meta-analysis of chemotherapy in head and neck cancer(MACH-NC):an update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group. Radiother Oncol 156:281-293, 2021
20)南 修司郎・他:頭頸部扁平上皮癌症例に対する3-WeeklyとWeekly CDDP併用化学放射線療法の臨床的検討.頭頸部癌42:428-431,2016
21)Buglione M, et al:Three weekly versus weekly concurrent cisplatin:safety propensity score analysis on 166 head and neck cancer patients. Radiat Oncol 16:239, 2021

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1316

印刷版ISSN:0914-3491

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