1)内閣府:平成30年版高齢社会白書 第1章第2節2健康・福祉.https://www8.cao.go.jp/kourei/whitepaper/w-2018/html/zenbun/s1_2_2.html(2019年5月23日閲覧)
2)厚生労働省:平成29年国民健康・栄養調査結果の概要.https://www.mhlw.go.jp/content/10904750/000351576.pdf(2019年5月23日閲覧)
3)Marshall S, et al:The consequences of malnutrition following discharge from rehabilitation to the community:a systematic review of current evidence in older adults. J Hum Nutr Diet 2014;27:133-141
4)Asakawa A, et al:Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001;120:337-345
5)鮫島奈々美,他:臨床に役立つQ & A 高齢者の食欲調節メカニズムと食思不振に対するアプローチについて教えてください.Geriatr Med 2017;55:781-785
6)太田大介:高齢者の食欲不振.成人病と生活習慣病2017;47:77-80
7)Wilson MM, et al:Appetite assessment:simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 2005;82:1074-1081
8)Nakatsu N, et al:Reliability and validity of the Japanese version of the simplified nutritional appetite questionnaire in community-dwelling older adults. Geriatr Gerontol Int 2015;15:1264-1269
9)土井剛彦:高齢者の症候 食欲の低下.日本臨牀2018;76:654-657
10)Tsutsumimoto K, et al:The association between anorexia of aging and physical frailty:Results from the national center for geriatrics and gerontology's study of geriatric syndromes. Maturitas 2017;97:32-37
11)Tokudome Y, et al:Development of the Japanese version of the Council on Nutrition Appetite Questionnaire and its simplified versions, and evaluation of their reliability, validity, and reproducibility. J Epidemiol 2017;27:524-530
12)和泉靖子,他:食欲が低下した患者への取り組み.徳島赤十字病医誌2013;18:97-101
13)日本緩和医療学会 緩和医療ガイドライン作成委員会(編):がんの補完代替療法クリニカル・エビデンス(2016年版).金原出版,2016
14)Fearon KC, et al:Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia:a randomised double blind trial. Gut 2003;52:1479-1486
15)加藤士郎,他:生活の中のリハビリテーションと食事.Geriatr Med 2018;56:379-383
16)Arai M, et al:Rikkunshito improves the symptoms in patients with functional dyspepsia, accompanied by an increase in the level of plasma ghrelin. Hepatogastroenterology 2012;59:62-66
17)Takeda H, et al:Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. Gastroenterology 2008;134:2004-2013
18)Fujitsuka N, et al:Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival. Transl Psychiatry 2011;1:e23. doi:10.1038/tp.2011.25.
19)Sadakane C, et al:10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation. Biochem Biophys Res Commun 2011;412:506-511
20)坂元隆一,他:漢方と脳卒中リハビリテーション医療.Jpn J Rehabil Med 2018;55:968-977
21)乾 明夫.フレイルと人参養栄湯.phil漢方2016;58:30-33
22)Rokot NT, et al:A role of ginseng and its constituents in the treatment of central nervous system disorders. Evid Based Complement Alternat Med 2016:2614742. doi:10.1155/2016/2614742
23)福永浩司,他:抑肝散加陳皮半夏のアルツハイマー病症状改善のメカニズム.phil漢方2016;60:32-33
24)Shin KY, et al:BT-11 is effective for enhancing cognitive functions in the elderly humans. Neurosci Lett 2009;465:157-159
25)Fujitsuka N, et al:Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1. Mol Psychiatry 2016;21:1613-1623
26)Goswami C, et al:Ninjin-yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia. Neuropeptides 2019;75:58-64
27)大澤匡弘,他:がん悪液質モデルの骨格筋量減少に対する人参養栄湯の効果.日心療内誌2018;22:93-100