1)日本集中治療医学会早期リハビリテーション検討委員会:集中治療における早期リハビリテーション—根拠に基づくエキスパートコンセンサス.日集中医誌2017;24:255-303
2)Devlin JW, et al:Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 2018;46:e825-e873
3)Dong Z, et al:Early rehabilitation therapy is beneficial for patients with prolonged mechanical ventilation after coronary artery bypass surgery. Int Heart J 2016;57:241-246
4)Fischer A, et al:Muscle mass, strength and functional outcomes in critically ill patients after cardiothoracic surgery:does neuromuscular electrical stimulation help? The Catastim 2 randomized controlled trial. Crit Care 2016;20:30. doi:10.1186/s13054-016-1199-3
5)Frazzitta G, et al:Effectiveness of a very early stepping verticalization protocol in severe acquired brain injured patients:a randomized pilot study in ICU. PLoS One 2016;11:e0158030. doi:10.1371/journal.pone.0158030
6)Hodgson CL, et al:A binational multicenter pilot feasibility randomized controlled trial of early goal-directed mobilization in the ICU. Crit Care Med 2016;44:1145-1152
7)Karadas C, et al:The effect of range of motion exercises on delirium prevention among patients aged 65 and over in intensive care units. Geriatr Nurs 2016;37:180-185
8)Morris PE, et al:Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure:a randomized clinical trial. JAMA 2016;315:2694-2702
9)Moss M, et al:A randomized trial of an intensive physical therapy program for patients with acute respiratory failure. Am J Respir Crit Care Med 2016;193:1101-1110
10)Schaller SJ, et al:Early, goal-directed mobilisation in the surgical intensive care unit:a randomised controlled trial. Lancet 2016;388:1377-1388
11)Stefanou C, et al:Neuromuscular electrical stimulation acutely mobilizes endothelial progenitor cells in critically ill patients with sepsis. Ann Intensive Care 2016;6:21. doi:10.1186/s13613-016-0123-y
12)Wright SE, et al:Intensive versus standard physical rehabilitation therapy in the critically ill(EPICC):a multicentre, parallel-group, randomised controlled trial. Thorax 2018;73:213-221
13)Akar O, et al:Efficacy of neuromuscular electrical stimulation in patients with COPD followed in intensive care unit. Clin Respir J 2017;11:743-750
14)Álvarez EA, et al:Occupational therapy for delirium management in elderly patients without mechanical ventilation in an intensive care unit:a pilot randomized clinical trial. J Crit Care 2017;37:85-90
15)Dall' Acqua AM, et al:Use of neuromuscular electrical stimulation to preserve the thickness of abdominal and chest muscles of critically ill patients:a randomized clinical trial. J Rehabil Med 2017;49:40-48
16)França EE, et al:Oxidative stress and immune system analysis after cycle ergometer use in critical patients. Clinics(Sao Paulo) 2017;72:143-149
17)Machado ADS, et al:Effects that passive cycling exercise have on muscle strength, duration of mechanical ventilation, and length of hospital stay in critically ill patients:a randomized clinical trial. J Bras Pneumol 2017;43:134-139
18)Tonella RM, et al:Inspiratory muscle training in the intensive care unit:a new perspective. J Clin Med Res 2017;9:929-934
19)Dos Santos FV, et al:Neuromuscular electrical stimulation combined with exercise decreases duration of mechanical ventilation in ICU patients:a randomized controlled trial. Physiother Theory Prac 2018:1-9. doi:10.1080/09593985.2018.1490363[Epub ahead of print]
20)Eggmann S, et al:Effects of early, combined endurance and resistance training in mechanically ventilated, critically ill patients:a randomised controlled trial. PLoS One 2018;13:e0207428. doi:10.1371/journal.pone.0207428
21)Fontes Cerqueira TC, et al:Ambulation capacity and functional outcome in patients undergoing neuromuscular electrical stimulation after cardiac valve surgery:a randomised clinical trial. Medicine(Baltimore) 2018;97:e13012. doi:10.1097/MD.0000000000013012
22)Fossat G, et al:Effect of in-bed leg cycling and electrical stimulation of the quadriceps on global muscle strength in critically ill adults:a randomized clinical trial. JAMA 2018;320:368-378
23)Koutsioumpa E, et al:Effect of transcutaneous electrical neuromuscular stimulation on myopathy in intensive care patients. Am J Crit Care 2018;27:495-503
24)Leite MA, et al:Effects of neuromuscular electrical stimulation of the quadriceps and diaphragm in critically ill patients:a pilot study. Crit Care Res Pract 2018;4298583. doi:10.1155/2018/4298583
25)Sosnowski K, et al:A feasibility study of a randomised controlled trial to examine the impact of the ABCDE bundle on quality of life in ICU survivors. Pilot Feasibility Stud 2018;4:32. doi:10.1186/s40814-017-0224-x
26)Kho ME, et al:Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients. BMJ Open Respir Res 2019;6:e000383. doi:10.1136/bmjresp-2018-000383
27)Sandoval Moreno LM, et al:Efficacy of respiratory muscle training in weaning of mechanical ventilation in patients with mechanical ventilation for 48 hours or more:a randomized controlled clinical trial. Med Intensiva 2019;43:79-89
28)Bakhru RN, et al:An environmental scan for early mobilization practice in U. S. ICUs. Crit Care Med 2015;43:2360-2369
29)Kelmenson DA, et al:Recovery from critical illness:physical rehabilitation in the intensive care unit, timing of persistent critical illness, and caregiver outcomes. Am J Respir Crit Care Med 2017;196:1068-1070
30)Connolly B, et al:Hindsight and moving the needle forwards on rehabilitation trial design. Thorax 2018;73:203-205
31)Denehy L, et al:Exercise rehabilitation for patients with critical illness:a randomized controlled trial with 12 months of follow-up. Crit Care 2013;17:R156. doi:10.1186/cc12835
32)Puthucheary ZA, et al:Exercise interventions in critical illness survivors:understanding inclusion and stratification criteria. Am J Respir Crit Care Med 2015;191:1464-1467
33)Schweickert WD, et al:Early physical and occupational therapy in mechanically ventilated, critically ill patients:a randomised controlled trial. Lancet 2009;373:1874-1882
34)Laterre PF, et al:Passive leg cycling and electrical stimulation cannot preserve strength in sepsis. Crit Care 2019;23:37. doi:10.1186/s13054-018-2226-3
35)Parker A, et al:Critical care rehabilitation trials:the importance of‘usual care’. Crit Care 2013;17:183. doi:10.1186/cc12884
36)Barr J, et al:Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 2013;41:263-306
37)Girard TD, et al:An official American Thoracic Society/American College of Chest Physicians clinical practice guideline:Liberation from mechanical ventilation in critically ill adults. Rehabilitation protocols, ventilator liberation protocols, and cuff leak tests. Am J Respir Crit Care Med 2017;195:120-133
38)Tipping CJ, et al:The effects of active mobilisation and rehabilitation in ICU on mortality and function:a systematic review. Intensive Care Med 2017;43:171-183
39)Fuke R, et al:Early rehabilitation to prevent postintensive care syndrome in patients with critical illness:a systematic review and meta-analysis. BMJ Open 2018;8:e019998. doi:10.1136/bmjopen-2017-019998
40)Barnes-Daly MA, et al:Improving hospital survival and reducing brain dysfunction at seven California community hospitals:implementing PAD guidelines via the ABCDEF bundle in 6,064 patients. Crit Care Med 2017;45:171-178
41)Pun BT, et al:Caring for critically ill patients with the ABCDEF bundle:results of the ICU liberation collaborative in over 15,000 adults. Crit Care Med 2019;47:3-14