理学療法ジャーナル56巻6号

2022年06月発行

特集 医療現場におけるサルコペニア・フレイル

脳血管疾患とサルコペニア・フレイル

著者： 野添匡史¹

所属機関： ¹甲南女子大学看護リハビリテーション学部理学療法学科

ページ範囲：P.630 - P.636

Point

●サルコペニア・フレイルは脳血管疾患発症後に生じるだけでなく，脳血管疾患発症にも関与している

●脳血管疾患の評価に合わせてサルコペニア・フレイルの原因も探索する必要がある

●急性期からサルコペニア・フレイルを予防する取り組みが重要になる

参考文献

1）Su Y, et al：Prevalence of stroke-related sarcopenia：a systematic review and meta-analysis. J Stroke Cerebrovasc Dis 2020 Sep；29：105092. doi：10.1016/j.jstrokecerebrovasdis.2020.105092

2）Kitamura A, et al：Sarcopenia：prevalence, associated factors, and the risk of mortality and disability in Japanese older adults. J Cachexia Sarcopenia Muscle 2021；12：30-38

3）Winovich DT, et al：Factors associated with ischemic stroke survival and recovery in older adults. Stroke 2017；48：1818-1826

4）Taylor-Rowan M, et al：The prevalence of frailty among acute stroke patients, and evaluation of method of assessment. Clin Rehabil 2019；33：1688-1696

5）Seamon BA, et al：The effect of frailty on discharge location for medicare beneficiaries after acute stroke. Arch Phys Med Rehabil 2019；100：1317-1323

6）Kanai M, et al：Pre-stroke frailty and stroke severity in elderly patients with acute stroke. J Stroke Cerebrovasc Dis 2020；29：105346. doi：10.1016/j.jstrokecerebrovasdis.2020.105346

7）Evans NR, et al：Clinical frailty independently predicts early mortality after ischaemic stroke. Age Ageing 2020；49：588-591

8）Palmer K, et al：Frailty syndromes in persons with cerebrovascular disease：a systematic review and meta-analysis. Front Neurol 2019；10：1255. doi：10.3389/fneur.2019.01255

9）Yoshimura Y, et al：Sarcopenia is associated with worse recovery of physical function and dysphagia and a lower rate of home discharge in Japanese hospitalized adults undergoing convalescent rehabilitation. Nutrition 2019；61：111-118

10）Kilkenny MF, et al：Utility of the Hospital Frailty Risk Score derived from administrative data and the association with stroke outcomes. Stroke 2021；52：2874-2881

11）Noguchi M, et al：Relationship between pre-stroke frailty status and short-term functional outcome in older patients with acute stroke—a mediation analysis. Arch Gerontol Geriatr 2021；94：104370. doi：10.1016/j.archger.2021.104370

12）Wæhler IS, et al：Association between in-hospital frailty and health-related quality of life after stroke：the Nor-COAST study. BMC Neurol 2021；21：100. doi：10.1186/s12883-021-02128-5

13）Taylor-Rowan M, et al：Pre-stroke frailty is independently associated with post-stroke cognition：a cross-sectional study. J Int Neuropsychol Soc 2019；25：501-506

14）Nozoe M, et al：Changes in quadriceps muscle thickness in acute non-ambulatory stroke survivors. Top Stroke Rehabil 2016；23：8-14

15）Li W, et al：New understanding of the pathogenesis and treatment of stroke-related sarcopenia. Biomed Pharmacother 2020；131：110721. doi：10.1016/j.biopha.2020.110721

16）Nozoe M, et al：Peripheral motor nerve conduction abnormality, muscle strength, and muscle wasting in patients with acute stroke：a pilot study. J Clin Neurosci 2020；75：80-84

17）Springer J, et al：Catabolic signaling and muscle wasting after acute ischemic stroke in mice：indication for a stroke-specific sarcopenia. Stroke 2014；45：3675-3683

18）Bernhardt J, et al：Inactive and alone：physical activity within the first 14 days of acute stroke unit care. Stroke 2004；35：1005-1009

19）Ryan AS, et al：Atrophy and intramuscular fat in specific muscles of the thigh：associated weakness and hyperinsulinemia in stroke survivors. Neurorehabil Neural Repair 2011；25：865-872

20）Chen N, et al：Risk factors for malnutrition in stroke patients：ameta-analysis. Clin Nutr 2019；38：127-135

21）Chen LK, et al：Asian Working Group for Sarcopenia：2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc 2020；21：300-307.e2. doi：10.1016/j.jamda.2019.12.012

22）Cruz-Jentoft AJ, et al：Sarcopenia：revised European consensus on definition and diagnosis. Age Ageing 2019；48：16-31

23）Nishioka S, et al：Validity of calf circumference for estimating skeletal muscle mass for Asian patients after stroke. Nutrition 2021；82：111028. doi：10.1016/j.nut.2020.111028

24）Inoue T, et al：Calf circumference value for sarcopenia screening among older adults with stroke. Arch Gerontol Geriatr 2021；93：104290. doi：10.1016/j.archger.2020.104290

25）Evans NR, et al：Frailty and cerebrovascular disease：concepts and clinical implications for stroke medicine. Int J Stroke 2022；17：251-259

26）Martone AM, et al：The incidence of sarcopenia among hospitalized older patients：results from the Glisten study. J Cachexia Sarcopenia Muscle 2017；8：907-914

27）日本脳卒中学会 脳卒中ガイドライン委員会（編）：脳卒中治療ガイドライン2021．協和企画，2021

28）Nagano F, et al：Muscle mass gain is positively associated with functional recovery in patients with sarcopenia after stroke. J Stroke Cerebrovasc Dis 2020；29：105017. doi：10.1016/j.strokecerebrovasdis.2020.105017

29）Matsushita T, et al：Effect of improvement in sarcopenia on functional and discharge outcomes in stroke rehabilitation patients. Nutrients 2021；13：2192. doi：10.3390/nu13072192

30）Aarden JJ, et al：Longitudinal changes in muscle mass, muscle strength, and physical performance in acutely hospitalized older adults. J Am Med Dir Assoc 2021；22：839-845.e1. doi：10.1016/j.jamda.2020.12.006

31）Tanaka S, et al：Relationship between longitudinal changes in skeletal muscle characteristics over time and functional recovery during intensive rehabilitation of patients with subacute stroke. Top Stroke Rehabil 2021 Jun 28：1-10. doi：10.1080/10749357.2021.1940724. Epub ahead of print

32）Yoshimura Y, et al：Chair-stand exercise improves post-stroke dysphagia. Geriatr Gerontol Int 2020；20：885-891

33）Nozoe M, et al：Physical activity, physical function, and quadriceps muscle thickness in male patients with sub-acute stroke during hospitalization：a pilot study. Eur Neurol 2018；80：157-162

34）Nozoe M, et al：Changes in quadriceps muscle thickness, disease severity, nutritional status, and C-reactive protein after acute stroke. J Stroke Cerebrovasc Dis 2016；25：2470-2474

35）Shimizu N, et al：Daytime physical activity at admission is associated with improvement of gait independence 1 month later in people with subacute stroke：a longitudinal study. Top Stroke Rehabil 2020；27：25-32

36）Shimizu A, et al：Comparison between the Global Leadership Initiative on Malnutrition and the European Society for Clinical Nutrition and Metabolism definitions for the prevalence of malnutrition in geriatric rehabilitation care. Geriatr Gerontol Int 2020；20：1221-1227

37）Yoshimura Y, et al：Stored energy increases body weight and skeletal muscle mass in older, underweight patients after stroke. Nutrients 2021；13：3274. doi：10.3390/nu13093274

38）Yoshimura Y, et al：Effects of a leucine-enriched amino acid supplement on muscle mass, muscle strength, and physical function in post-stroke patients with sarcopenia：a randomized controlled trial. Nutrition 2019；58：1-6. doi：10.1016/j.nut.2018.05.028