理学療法ジャーナル56巻6号

2022年06月発行

特集 医療現場におけるサルコペニア・フレイル

内分泌代謝疾患とサルコペニア・フレイル

著者： 浅田史成¹

所属機関： ¹大阪労災病院治療就労両立支援センター両立支援部門

ページ範囲：P.657 - P.662

Point

●糖尿病を中心とする内分泌疾患はサルコペニア・フレイルのリスク要因の一つである

●内分泌疾患とサルコペニア・フレイルは相互に関連し悪循環をなす

●内分泌疾患を有する患者のサルコペニア・フレイルの予防・治療には運動，食事の改善が必須である

参考文献

1）Ali S, et al：Sarcopenia, cachexia and aging：diagnosis, mechanisms and therapeutic options—a mini-review. Gerontology 2014；60：294-305

2）Park SW, et al：Decreased muscle strength and quality in older adults with type 2 diabetes：the health, aging, and body composition study. Diabetes 2006；55：1813-1818

3）Park SW, et al：Health, aging, and body composition study. Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes：the health, aging, and body composition study. Diabetes Care 2007；30：1507-1512

4）Asada F, et al：Lower-limb muscle strength according to bodyweight and muscle mass among middle age patients with type 2 diabetes without diabetic neuropathy. J Phys Ther Sci 2017；29：1181-1185

. J Clin Endocrinol Metab 2016；101：3676-3684

6）Volpato S, et al：Role of muscle mass and muscle quality in the association between diabetes and gait speed. Diabetes Care 2012；35：1672-1679

7）Yoshida D, et al：Using two different algorithms to determine the prevalence of sarcopenia. Geriatr Gerontol Int 2014；14（Suppl 1）：46-51

8）Yoshimura N, et al：Is osteoporosis a predictor for future sarcopenia or vice versa? Four-year observations between the second and third ROAD study surveys. Osteoporos Int 2017；28：189-199

9）Kim TN, et al：Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes：the Korean Sarcopenic Obesity Study（KSOS）. Diabetes Care 2010；33：1497-1499

10）Chung SM, et al：Prevalence of sarcopenia and its association with diabetes：a meta-analysis of community-dwelling Asian population. Front Med（Lausanne）202120；8：681232. doi：10.3389/fmed.2021.681232

11）Fukuoka Y, et al：Importance of physical evaluation using skeletal muscle mass index and body fat percentage to prevent sarcopenia in elderly Japanese diabetes patients. J Diabetes Investig 2019；10：322-330

12）Mori H, et al：Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes. J Diabetes Investig 2017；8：377-382

13）Mori H, et al：High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes：findings from the Impact of Diabetes Mellitus on Dynapenia study. J Diabetes Investig 2021；12：1050-1059

14）Sugimoto K, et al：Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass：the multicenter study for clarifying evidence for sarcopenia in patients with diabetes mellitus. J Diabetes Investig 2019；10：1471-1479

15）García-Esquinas E, et al：Diabetes and risk of frailty and its potential mechanisms：a prospective cohort study of older adults. J Am Med Dir Assoc 2015；16：748-754

16）Espinoza SE, et al：Frailty transitions in the San Antonio longitudinal study of aging. J Am Geriatr Soc 2012；60：652-660

17）Veronese N, et al：Frailty ss associated with an increased risk of incident type 2 diabetes in the elderly. J Am Med Dir Assoc 2016；17：902-907

18）Kalyani RR, et al：Frailty status and altered glucose-insulin dynamics. J Gerontol A Biol Sci Med Sci 2012；67：1300-1306

19）Choi MH, et al：Oxidative stress-mediated skeletal muscle degeneration：molecules, mechanisms, and therapies. Oxid Med Cell Longev 2016；2016：6842568. doi：10.1155/2016/6842568

20）Sinclair A, et al：Diabetes in older people：new insights and remaining challenges. Lancet Diabetes Endocrinol 2015；3：275-285

21）Sinclair AJ, et al：Frailty and sarcopenia—newly emerging and high impact complications of diabetes. J Diabetes Complications 2017；31：1465-1473

22）Chao CT, et al：Cohort of geriatric nephrology in NTUH（COGENT）study group. Hypoglycemic episodes are associated with an increased risk of incident frailty among new onset diabetic patients. J Diabetes Complications 2020；34：107492. doi：10.1016/j.jdiacomp.2019.107492

23）Ishikawa S, et al：Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease. PLoS One 2018；13：e0192990. doi：10.1371/journal.pone.0192990

24）Pereira RA, et al：Sarcopenia in chronic kidney disease on conservative therapy：prevalence and association with mortality. Nephrol Dial Transplant 2015；30：1718-1725

25）Mori K, et al：Impact of diabetes on sarcopenia and mortality in patients undergoing hemodialysis. BMC Nephrol 2019；20：105. doi：10.1186/s12882-019-1271-8

26）Ida S, et al：Association between sarcopenia and renal function in patients with diabetes：a systematic review and meta-analysis. J Diabetes Res 2019；2019：1365189. doi：10.1155/2019/1365189

27）西口修平，他：肝疾患におけるサルコペニアの判定基準（第1版）．肝臓2016；57：353-368

28）Hanai T, et al：Rapid skeletal muscle wasting predicts worse survival in patients with liver cirrhosis. Hepatol Res 2016；46：743-751

29）Krause MP, et al：Effects of type 1 diabetes mellitus on skeletal muscle：clinical observations and physiological mechanisms. Pediatr Diabetes 2011；12：345-364

30）Fortes MAS, et al：Hypertrophy stimulation at the onset of type Ⅰ diabetes maintains the soleus but not the EDL muscle mass in Wistar rats. Front Physiol 2017；8：830. doi：10.3389/fphys.2017.00830

31）Landi F, et al：Sarcopenia and diabetes：two sides of the same coin. J Am Med Dir Assoc 2013；14：540-541

32）Hirata Y, et al：Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis. JCI Insight 2019；4：e124952. doi：10.1172/jci.insight.124952

33）Stephen WC, et al：Sarcopenic-obesity and cardiovascular disease risk in the elderly. J Nutr Health Aging 2009；13：460-466

34）Baumgartner RN：Body composition in healthy aging. Ann N Y Acad Sci 2000；904：437-448

35）Ishii S, et al：The association between sarcopenic obesity and depressive symptoms in older Japanese adults. PLoS One 2016；11：e0162898. doi：10.1371/journal.pone.0162898

36）Ibáñez J, et al：Lower muscle strength gains in older men with type 2 diabetes after resistance training. J Diabetes Complications 2008；22：112-118

37）Lee J, et al：Resistance training for glycemic control, muscular strength, and lean body mass in old type 2 diabetic patients：a meta-analysis. Diabetes Ther 2017；8：459-473

38）Muscariello E, et al：Dietary protein intake in sarcopenic obese older women. Clin Interv Aging 2016；11：133-140

39）Kim H, et al：Exercise and nutritional supplementation on community-dwelling elderly Japanese women with sarcopenic obesity：a randomized controlled trial. J Am Med Dir Assoc 2016；17：1011-1019

40）Lee CG, et al；Osteoporotic Fractures in Men（MrOS）Study Research Group：Insulin sensitizers may attenuate lean mass loss in older men with diabetes. Diabetes Care 2011；34：2381-2386

41）Lee CG, et al；Study of Osteoporotic Fractures Research Group：Changes in physical performance in older women according to presence and treatment of diabetes mellitus. J Am Geriatr Soc 2013；61：1872-1878

42）Sinclair AJ, et al：An international position statement on the management of frailty in diabetes mellitus：summary of recommendations 2017. J Frailty Aging 2018；7：10-20

43）Santanasto AJ, et al：Impact of weight loss on physical function with changes in strength, muscle mass, and muscle fat infiltration in overweight to moderately obese older adults：a randomized clinical trial. J Obes 2011；2011：516576. doi：10.1155/2011/516576

44）Villareal DT, et al：Aerobic or resistance exercise, or both, in dieting obese older adults. N Engl J Med 2017；376：1943-1955

45）Chen SM, et al：Effects of resistance exercise on glycated hemoglobin and functional performance in older patients with comorbid diabetes mellitus and knee osteoarthritis：a randomized trial. Int J Environ Res Public Health 2019；17：224. doi：10.3390/ijerph17010224