BRAIN and NERVE－神経研究の進歩59巻7号

2007年07月発行

増大特集 情報伝達処理におけるグリアの機能と異常

シナプス・グリア動態の可視化

著者： 西田秀子¹² 岡部繁男¹²

所属機関： ¹東京医科歯科大学大学院医歯学総合研究科細胞生物学 ²東京医科歯科大学21世紀COEプログラム「脳の機能統合とその失調」

ページ範囲：P.755 - P.761

文献概要

　情報を送る神経と受け取る神経からなるシナプスに，その直近に存在するグリア細胞を付け加えた“Tripartite synapse（三者から成るシナプス）”^1）という言葉が初めて使われて8年が経ち，アストロサイトがシナプス伝達を積極的に修飾していることを支持する非常に多くの知見が集積してきた。しかしながら，それらの多くは電気生理実験から得られたものであり，それに比して形態学的証拠はいまだ非常に少ない。本稿では，アストロサイトとシナプス構造の形態学的解析について，まずさきがけとなった固定標本による解析を簡単に紹介する。そのあと，本稿の主題である，近年相次いで報告された，生きた組織におけるアストロサイトとシナプス構造の可視化技術と，その技術によって可能となった観察およびその結果について紹介したい。

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