BRAIN and NERVE－神経研究の進歩60巻11号

2008年11月発行

特集 脳卒中と遺伝子

VWF切断酵素ADAMTS13の遺伝子多型

著者： 小亀浩市¹

所属機関： ¹国立循環器病センター研究所

ページ範囲：P.1325 - P.1332

文献概要

はじめに

　血小板の凝集は，生体防御機構の1つとして極めて重要な生理反応であると同時に，血栓症のもととなる血栓を形成する反応である。血小板凝集反応は，血小板だけでなく，血管壁細胞や血漿成分など，さまざまな因子によって制御されている。本稿では，VWF切断酵素であるADAMTS13について，その構造的および機能的特徴や疾患との関連を概述し，さらに，遺伝子多型に関する知見を紹介する。

参考文献

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