BRAIN and NERVE－神経研究の進歩61巻2号

2009年02月発行

特集 神経系の再興感染症と輸入感染症

新型インフルエンザと脳炎・脳症

著者： 玉記雷太¹ 神垣太郎¹ 押谷仁¹

所属機関： ¹東北大学大学院医学系研究科病理病態学講座微生物学分野

ページ範囲：P.153 - P.160

文献概要

はじめに

　新興・再興感染症の中でも新型インフルエンザは，単なる一感染症ではなく，社会に甚大な被害を与えることが予測されており，世界的な懸念が高まっている。新型インフルエンザは，実際に発生してみないとそのウイルスの特性がわからないため，最悪の事態を想定した準備が必要となる。臨床的にも，新型インフルエンザウイルスによる感染例では，肺炎等の呼吸器系の合併症だけでなく，脳炎・脳症等の中枢神経系の合併症も数多く報告されている。本稿において過去の新型インフルエンザにみられる中枢神経症や，近年本邦で問題となっている小児のインフルエンザ脳症をレビューし，インフルエンザによる中枢神経疾患の病理・病態を考察する。また，現在流行している鳥インフルエンザ（H5N1）のヒト感染例の臨床像を，中枢神経症を中心に概括したい。

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