BRAIN and NERVE－神経研究の進歩61巻6号

2009年06月発行

総説

悪性脳腫瘍の放射線治療における高気圧酸素の応用―現状と今後

著者： 別府高明¹ 田中克之² 合志清隆³

所属機関： ¹岩手医科大学脳神経外科・高気圧環境医学 ²聖マリアンナ医科大学脳神経外科 ³

ページ範囲：P.677 - P.681

文献概要

Ⅰ．はじめに

　高気圧酸素治療（hyperbaric oxygenation：HBO）は2～3気圧下での酸素療法であり，一般には減圧障害，ガス塞栓症，一酸化炭素中毒などで低酸素に陥った組織の酸素化に用いられる。一方で酸素化は細胞傷害を増強させることから，HBOは細菌感染症や癌の治療に応用されている。癌治療への応用では，HBOが放射線治療や化学療法の効果を増強する可能性が示唆されている。放射線治療（radiotherapy：RT）との併用は1950年代から試みられ，頭頸部癌と子宮頸癌ではランダム化比較試験（RCT）にて有効性が確認されている^1）。さらに，HBOは放射線治療による腫瘍周囲の放射線障害に対しても用いられている。本稿では，主に悪性脳腫瘍の放射線治療におけるHBOの応用の現状と可能性を紹介する。

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