BRAIN and NERVE－神経研究の進歩63巻7号

2011年07月発行

増大特集 神経筋接合部―基礎から臨床まで

神経筋接合部形成の分子機構

著者： 樋口理¹² 山梨裕司¹

所属機関： ¹東京大学医科学研究所腫瘍抑制分野 ²国立病院機構長崎川棚医療センター臨床研究部免疫ゲノム医化学研究室

ページ範囲：P.649 - P.655

文献概要

はじめに

　神経筋接合部（neuromuscular junction：NMJ）は，運動神経と骨格筋の間に構成されるシナプスである。このシナプスの形成過程には多くの遺伝子が関与することが既に明らかにされている。本稿では，その中でも最近特に注目を集めている3つの遺伝子，Dok-7，LDL receptor-related protein 4（Lrp4），cyclin-dependent kinase 5（Cdk5）に関する話題を中心に最新の知見も含めて紹介したい。

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