BRAIN and NERVE－神経研究の進歩64巻4号

2012年04月発行

増大特集 パーキンソン病の新しい側面

パーキンソン病における脳波・事象関連電位による解析

著者： 亀井聡¹

所属機関： ¹日本大学医学部内科学系神経内科学分野

ページ範囲：P.433 - P.443

文献概要

はじめに

　パーキンソン病（Parkinson disease：PD）の原著では，“senses and the intellect remain uninjured”と記載された。しかしその後，認知症（dementia）を含む認知機能障害（cognitive impairment）は，本症の非運動徴候の1つとして知られ，患者の日常生活動作（activities of daily living：ADL）を阻害する大きな要因として注目されている。このようなPDの認知機能を検討する手法として，脳波（electroencephalogram：EEG）を基盤にした脳波周波数解析（quantitative EEG：qEEG）や事象関連電位（event-related potentials：ERP）が挙げられる。本稿では，PDにおけるqEEGとERPについて最近の動向を踏まえ概説する。

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