BRAIN and NERVE－神経研究の進歩65巻4号

2013年04月発行

増大特集 Antibody Update

VGKC関連抗体

著者： 渡邊修¹

所属機関： ¹鹿児島大学大学院医歯学総合研究科神経内科・老年病学

ページ範囲：P.401 - P.411

文献概要

はじめに

　電位依存性カリウムチャネル（voltage-gated potassium channel：VGKC）関連抗体の代表的なものは，VGKCのリガンドである¹²⁵I-αデンドロトキンを用いたRIA（radioimmunoassay）法により検出される抗VGKC複合体抗体である。この抗体は，以前は，単に「抗VGKC抗体」と称されていたが，その後の研究でVGKCそのもののみならず，VGKCと複合体を形成する種々の分子に対する抗体を網羅するものであることが最近の研究で明らかになった（Table1）。

　このRIA法によるスクリーニング検査で検出されないVGKCに関連する新たな抗体の報告もあるが¹⁾，本稿では，抗VGKC複合体抗体を中心に取り上げ，作用機序や疾患との関連性について概説する。また，てんかんや疼痛との関連や，クロイツフェルト・ヤコブ病（Creutzfeldt-Jakob disease：CJD）や筋萎縮性側索硬化症（amyotrophic lateral sclerosis：ALS）と本抗体との関連性についても触れてみたい。

参考文献

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