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文献概要
はじめに
自己免疫性重症筋無力症（autoimmune myasthenia gravis：MG）は神経筋接合部におけるアセチルコリン受容体（AChR）あるいは筋特異的チロシンキナーゼ（MuSK）に対する自己抗体が原因となる臓器特異性自己免疫疾患である1,2)。全身の骨格筋における易疲労性と筋力低下などの運動症状がMGの主要な症状である。
近年，パーキンソン病をはじめとする神経疾患において運動症状以外にも多彩な非運動症状（non-motor symptoms）が認められることが広く知られている。これまで注目されてこなかったものの，MG患者において非運動症状が出現し，運動症状よりも患者QOL（quality of life）に大きな影響を与える可能性がある。
自己免疫性重症筋無力症（autoimmune myasthenia gravis：MG）は神経筋接合部におけるアセチルコリン受容体（AChR）あるいは筋特異的チロシンキナーゼ（MuSK）に対する自己抗体が原因となる臓器特異性自己免疫疾患である1,2)。全身の骨格筋における易疲労性と筋力低下などの運動症状がMGの主要な症状である。
近年，パーキンソン病をはじめとする神経疾患において運動症状以外にも多彩な非運動症状（non-motor symptoms）が認められることが広く知られている。これまで注目されてこなかったものの，MG患者において非運動症状が出現し，運動症状よりも患者QOL（quality of life）に大きな影響を与える可能性がある。
参考文献
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