BRAIN and NERVE－神経研究の進歩65巻7号

2013年07月発行

増大特集 あしたの脳梗塞

加齢性白質病変（leukoaraiosis）update

著者： 三木幸雄¹ 坂本真一¹

所属機関： ¹大阪市立大学放射線医学教室

ページ範囲：P.789 - P.799

文献概要

はじめに

　高齢者の脳の磁気共鳴画像（magnetic resonance imaging：MRI）のT₂強調画像やFLAIR（fluid-attenuated inversion recovery）画像では，高頻度に大脳白質に高信号領域が観察される。脳のMRI検査において，最も頻繁に目にする病変である¹⁾。最近では，脳小血管病（cerebral small vessel disease）としても注目され，多くの前向き研究により，脳卒中や認知症などの重要なリスクファクターの1つであることが明らかになってきている^2-8)。以前は，何を見ているかよくわかっていなかったことから，UBO（unidentified bright object）とも呼ばれたことがあるが，現在では，多くの，画像と病理との対比研究により，「何を見ているか」がわかってきた。本稿では，高齢者における大脳白質病変について，最近の知見を含め，概説する。

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