BRAIN and NERVE－神経研究の進歩66巻1号

2014年01月発行

特集 日常生活の脳科学

やめたいけどやめられない―喫煙欲求と自己制御の神経機構

著者： 林拓也¹

所属機関： ¹独立行政法人理化学研究所ライフサイエンス技術基盤研究センター機能構築イメージングユニット

ページ範囲：P.33 - P.39

文献概要

喫煙欲求や薬物欲求は依存症の病態の本質で，薬物探索行動やその再発に重要な要因と考えられてきた。しかし行動経済学・心理学で欲求の研究が進むと，文脈や時間依存性の変化が大きいことが知られるようになった。脳機能画像法でも欲求関連脳活動の同定が進むにつれ文脈依存性の変動が明らかになった。これら文脈依存性は合理的意思決定論の導入により理論化され，前頭前野の機能的回路形成が自己制御と薬物欲求を担うこともわかってきた。

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