BRAIN and NERVE－神経研究の進歩66巻3号

2014年03月発行

総説

視神経損傷モデルにおける神経再生，神経回路再形成および視機能回復の分子機構

著者： 郡山恵樹¹²³ 栗本拓治²³⁴ デリマシウマラ²³⁵ ベノヴィッツラリー²³

所属機関： ¹金沢大学医薬保健研究域医学系脳情報分子学 ²ボストン小児病院神経外科学/神経生物学 ³ハーバード大学医学部外科/眼科学 ⁴大阪医科大学眼科学教室 ⁵リオデジャネイロ連邦大学生物医学研究所

ページ範囲：P.265 - P.272

文献概要

視神経は網膜神経節細胞の軸索束であり中枢神経再生のメカニズム研究に広く用いられてきた。近年，部分的な視神経再生が起こる分子メカニズムについてさまざまな報告がなされてきたが，より多くの再生線維が視覚中枢まで正しく再投射した際の視機能回復を証明した論文は皆無であった。本稿では眼炎症，cAMP，脱リン酸化酵素PTEN欠損のコンビネーション処理によって著しい視神経再生と視機能回復が成功した例をまとめた。

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