BRAIN and NERVE－神経研究の進歩66巻9号

2014年09月発行

総説

脳の機能発達を担うシナプス刈り込みの機構

著者： 上阪直史¹ 川田慎也¹ 狩野方伸¹

所属機関： ¹東京大学大学院医学系研究科神経生理学教室

ページ範囲：P.1069 - P.1077

文献概要

生後間もない時期の動物の脳には，成熟動物の脳と比較して，過剰なシナプスが存在する。生後発達過程において，このうち必要なシナプス結合が強められ，不要な結合は除去されて，成熟した機能的な神経回路が完成する。この過程は「シナプス刈り込み」と呼ばれており，生後発達期の神経系にみられる普遍的な現象であると考えられている。最近の研究により，シナプス刈り込みの細胞・分子機構が明らかになりつつある。

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