BRAIN and NERVE－神経研究の進歩67巻11号

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増大特集 ギラン・バレー症候群のすべて—100年の軌跡

ギラン・バレー症候群の末梢神経病理

著者： 中野雄太¹ 神田隆¹

所属機関： ¹山口大学大学院医学系研究科神経内科学

ページ範囲：P.1329 - P.1339

ギラン・バレー症候群（GBS）は，当初報告された脱髄主体の急性炎症性脱髄性多発ニューロパチー（AIDP）に加えて，現在では急性運動性軸索型ニューロパチー（AMAN）や急性運動感覚性軸索型ニューロパチー（AMSAN）といった軸索障害主体の病型の存在が確立している。各病型の病理学的特徴は，脱髄型では血液神経関門の破綻部位に一致した巣状散在性の炎症性脱髄巣であり，軸索型では神経根に強調される軸索傷害巣である。本稿では，病態機序との相関に重点を置いてGBSの末梢神経病理について概説する。

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