BRAIN and NERVE－神経研究の進歩67巻11号

2015年11月発行

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増大特集 ギラン・バレー症候群のすべて—100年の軌跡

分子相同性によるギラン・バレー症候群の発症機序—病態解明の道程

著者： 結城伸泰¹

所属機関： ¹シドニー大学脳精神センター

ページ範囲：P.1341 - P.1346

ギラン・バレー症候群（GBS）の3割がCampylobacter jejuni腸炎後に発症する。C. jejuniリポオリゴ糖とガングリオシドとの間に分子相同性が存在する。C. jejuni感染後5,000人に1人の割合で抗ガングリオシド抗体が産生され，末梢運動神経に結合し，補体が活性化される。続いて，軸索膜が傷害され，伝導障害が起こり，運動麻痺を呈する。

参考文献

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