BRAIN and NERVE－神経研究の進歩67巻12号

2015年12月発行

特集 視床と高次脳機能

視床と情動

著者： 平山和美¹

所属機関： ¹山形県立保健医療大学作業療法学科

ページ範囲：P.1499 - P.1508

文献概要

視床背内側核は情動の形成に重要な基底外側辺縁回路と前頭葉-皮質下回路の一要素である。視床下部は基底外側辺縁回路と連結している。視床背内側核や視床下部が損傷すると，発現する情動に異常が生じる。視床枕は上丘-視床枕-扁桃体経路の一要素として，生態学的に重要な視覚情報の，無意識的な処理や意識的ですばやい処理に関わる。視床枕が損傷すると，視覚的脅かしや恐怖の表情が短時間だけ提示されたとき，反応に異常が生じる。

参考文献

1) 久保ゆかり: 感情. 下山晴彦, 大塚雄作, 遠藤利彦, 齋木　潤, 中村知靖（編): 心理学辞典. 誠信書房, 東京, 2014, pp286-326

2) 向田久美子: 感情. 下山晴彦, 大塚雄作, 遠藤利彦, 齋木　潤, 中村知靖（編): 心理学辞典. 誠信書房, 東京, 2014, pp327-350

3) Livingstone KE, Escobar A: Anatomical bias of limbic system concept. A proposed reorientation. Arch Neurol 24: 17-21, 1971

4) Davidson RJ, Irwin W: The functional neuroanatomy of emotion and affective style. Trends Cogn Sci 3: 11-21, 1999

5) Cummings JL: Frontal-subcortical circuits and human behavior. Arch Neurol 50: 873-880, 1993

6) Metzger CD, Eckert U, Steiner J, Sartorius A, Buchmann JE, et al: High field fMRI reveals thalamocortical integration of segregated cognitive and emotional processing in mediodorsal and intralaminar thalamic nuclei. Front Neuroanat 4: 138, 2010

7) 浜中淑彦, 東村輝彦: 「痛覚失象徴症」について. 精神神経誌69: 545-554, 1967

8) Hermann DM, Siccoli M, Brugger P, Wachter K, Mathis J, et al: Evolution of neurological, neuropsychological and sleep-wake disturbances after paramedian thalamic stroke. Stroke 39: 62-68, 2008

9) Gentilini M, De Renzi E, Crisi G: Bilateral paramedian thalamic artery infarcts: report of eight cases. J Neurol Neurosurg Psychiatry 50: 900-909, 1987

10) Mutarelli EG, Omuro AMP, Adoni T: Hypersexuality following bilateral thalamic infarction: case report. Arq Neuropsiquiatr 64: 146-148, 2006

11) Van der Werf YD, Scheltens P, Lindeboom J, Witter MP, Uylings HB, et al: Deficits of memory, executive functioning and attention following infarction in the thalamus; a study of 22 cases with localised lesions. Neuropsychologia 41: 1330-1344, 2013

12) Fukatsu R, Fujii T, Yamadori A, Nagasawa H, Sakurai Y: Persisting childish behavior after bilateral thalamic infarcts. Eur Neurol 37: 230-235, 1997

13) Muroi A, Hirayama K, Tanno Y, Shimizu S, Watanabe T, et al: Cassation of stuttering after bilateral thalamic infarction. Neurology 53: 890-891, 1999

14) Sano K, Mayanagi Y, Sekino H, Ogashiwa M, Ishijima B: Results of stimulation and destruction of the posterior hypothalamus in man. J Neurosurg 33: 689-707, 1970

15) Reeves AG, Plum F: Hyperphagia, rage, and dementia accompanying a ventromedial hypothalamic neoplasm. Arch Neurol 20: 616-624, 1969

16) Monroe RR, Heath RC: Psychiatric observation on the patient group. Heath RC (ed): Studies in Schizophrenia: a Multidiscliplinary Approach to Mind-Brain Relationships. Harvard University Press, Cambridge, 1954, pp345-383

17) Quaade F, Vaernet K, Larsson S: Stereotaxic stimulation and electrocoagulation of the lateral hypothalamus in obese humans. Acta Neurochir (Wien) 30: 111-117, 1974

18) Berkovic SF, Andermann F, Melanson D, Ethier RE, Feindel W, et al: Hypothalamic hamartomas and ictal laughter: evolution of a characteristic epileptic syndrome and diagnostic value of magnetic resonance imaging. Ann Neurol 23: 429-439, 1988

19) Sturm JW, Andermann F, Berkovic SF: "Pressure to laugh": an unusual epileptic symptom associated with small hypothalamic hamartomas. Neurology 54: 971-973, 2000

20) Weddell RA: Effects of subcortical lesion site on human emotional behavior. Brain Cogn 25: 161-193, 1994

21) Grieve KL, Acuña C, Cudeiro J: The primate pulvinar nuclei: vision and action. Trends Neurosci 23: 35-39, 2000

22) Weiskrantz L: Blindsight: A Case Study and Implications. Oxford University Press, Oxford, 1986

23) Morris JS, Öhman A, Dolan RJ: A subcortical pathway to the right amygdala mediating "unseen" fear. Proc Natl Acad Sci U S A 96: 1680-1685, 1999

24) Pegna AJ, Khateb A, Lazeyras F, Seghier ML: Discriminating emotional faces without primary visual cortices involves the right amygdala. Nat Neurosci 8: 24-25, 2005

25) Ward R, Danziger S, Bamford S: Response to visual threat following damage to the pulvinar. Curr Biol 15: 571-573, 2005

26) Ward R, Calder AJ, Parker M, Arend I: Emotion recognition following human pulvinar damage. Neuropsychologia 45: 1973-1978, 2007

27) Romanski LM, Giguere M, Bates JF, Goldman-Rakic PS: Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey. J Comp Neurol 379: 313-332, 1997

28) Van Le Q, Isbell LA, Matsumoto J, Nguyen M, Hori E, et al: Pulvinar neurons reveal neurobiological evidence of past selection for rapid detection of snakes. Proc Natl Acad Sci U S A 110: 19000-19005, 2013

29) Almeida I, Soares SC, Castelo-Branco M: The distinct role of the amygdala, superior colliculus and pulvinar in processing of central and peripheral snakes. PLOS ONE 9: e0129949, 2015