icon fsr

文献詳細

雑誌文献

BRAIN and NERVE-神経研究の進歩67巻2号

2015年02月発行

特集 「食べる」を考える

摂食行動および食欲の神経基盤

著者: 桜井武1

所属機関: 1金沢大学医薬保健研究域医学系分子神経科学・統合生理学

ページ範囲:P.131 - P.139

文献概要

レプチンの発見以来,その作用機序の探索により,視床下部を中心とした神経系による摂食行動の制御機構が少しずつ明らかになりつつある。視床下部では,多くの神経ペプチドとそれらを産生するニューロン群が摂食行動の制御に深く関わることが解明されてきた。近い将来,視床下部のシステムが脳の広範なシステムに働いて摂食行動が制御されるメカニズムの全貌が明らかになることが期待される。

参考文献

1) Hetherington AW, Ranson SW: The spontaneous activiy and food intake of rats with hypothalamic lesions. Am J Physiolol 136: 609-617, 1942
2) Anand BK, Brobeck JR: Hypothalamic control of food intake in rats and cats. Yale J Biol Med 24: 123-140, 1951
3) Hervey GR: The effects of lesions in the hypothalamus in parabiotic rats. J Physiol 145: 336-352, 1959
4) Kennedy GC: The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci 140: 578-596, 1953
5) Coleman DL, Hummel KP: Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 217: 1298-1304, 1969
6) Coleman DL: Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9: 294-298, 1973
7) Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, et al: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387: 903-908, 1997
8) Tartaglia LA1, Dembski M, Weng X, Deng N, Culpepper J, et al: Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271, 1995
9) Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, et al: Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491-495, 1996
10) Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, et al: The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377: 530-532, 1995
11) Erickson JC, Hollopeter G, Palmiter RD: Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274: 1704-1707, 1996
12) Erickson JC, Clegg KE, Palmiter RD: Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381: 415-421, 1996
13) Morgan WC: The relation of the lethal yellow (Ay) gene to pulmonary tumor formation and obesity in an inbred strain of mice. J Natl Cancer Inst 11: 263-268, 1950
14) Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD: Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385: 165-168, 1997
15) Jackson RS, Creemers JW, Ohagi S, Raffin-Sanson ML, Sanders L, et al: Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 16: 303-306, 1997
16) Krude H, Biebermann H, Luck W, Horn R, Brabant G, et al: Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19: 155-157, 1998
17) Linhart KB, Majzoub JA: Pomc knockout mice have secondary hyperaldosteronism despite an absence of adrenocorticotropin. Endocrinology 149: 681-686, 2008
18) Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, et al: Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88: 131-141, 1997
19) Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, et al: Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278: 135-138, 1997
20) Douglass J, Daoud S: Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript. Gene 169: 241-245, 1996
21) van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, et al: Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149: 1773-1785, 2008
22) Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, et al: Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49: 191-203, 2006
23) Bingham NC, Anderson KK, Reuter AL, Stallings NR, Parker KL: Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 149: 2138-2148, 2008
24) Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, et al: Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38: 701-713, 2003
25) Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, et al: Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 51: 801-810, 2006
26) Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, et al: Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449: 228-232, 2007
27) Mountjoy PD, Bailey SJ, Rutter GA: Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity. Diabetologia 50: 168-177, 2007
28) Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, et al: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660, 1999
29) Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, et al: A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380: 243-247, 1996
30) Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E: Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396: 670-674, 1998
31) Saito Y, Cheng M, Leslie FM, Civelli O: Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J Comp Neurol 435: 26-40, 2001
32) Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, et al: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 1 page following 696, 1998
33) Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, et al: Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98: 437-451, 1999
34) Lin L, Faraco J, Li R, Kadotani H, Rogers W, et al: The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98: 365-376, 1999
35) Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, et al: Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron 46: 297-308, 2005
36) Harris GC, Wimmer M, Aston-Jones G: A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437: 556-559, 2005
37) Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, et al: Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.J Biol Chem 278: 27652-27657, 2003
38) Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, et al: A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc Natl Acad Sci U S A 103: 7438-7443, 2006
39) Atasoy D, Betley JN, Su HH, Sternson SM: Deconstruction of a neural circuit for hunger. Nature 488: 172-177, 2012
40) Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, et al: AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569-574, 2004
41) Frank S, Heni M, Moss A, von Schnurbein J, Fritsche A, et al: Leptin therapy in a congenital leptin-deficient patient leads to acute and long-term changes in homeo-static, reward, and food-related brain areas. J Clin Endocrinol Metab 96: E1283-1287, 2011
42) Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S, et al: Leptin regulates striatal regions and human eating behavior. Science 317: 1355, 2007

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1344-8129

印刷版ISSN:1881-6096

雑誌購入ページに移動
icon up

本サービスは医療関係者に向けた情報提供を目的としております。
一般の方に対する情報提供を目的としたものではない事をご了承ください。
また,本サービスのご利用にあたっては,利用規約およびプライバシーポリシーへの同意が必要です。

※本サービスを使わずにご契約中の電子商品をご利用したい場合はこちら