BRAIN and NERVE－神経研究の進歩67巻3号

2015年03月発行

総説

パーキンソン病・アルツハイマー病における時間認知障害

著者： 本間元康¹ 黒田岳志¹ 二村明徳¹ 杉本あずさ¹ 河村満¹

所属機関： ¹昭和大学医学部内科学講座神経内科部門

ページ範囲：P.297 - P.302

文献概要

時間認知はさまざまな要因によって変化し，その脳内処理は複雑である。近年いくつかの研究は，特定の神経疾患患者で時間認知が短くなることを報告している。本稿では，時間認知の処理モデルを踏まえながら，パーキンソン病とアルツハイマー病における時間認知障害を概説する。それら2つの疾患は似たタイプの時間認知障害を示すが，その背景メカニズムは大きく異なる。パーキンソン病の時間認知障害はペースメーカーをつかさどる線条体の異常を中心に，一方，アルツハイマー病の障害は記憶をつかさどる海馬の異常を中心に起きている可能性が考えられる。

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