BRAIN and NERVE－神経研究の進歩67巻4号

2015年04月発行

増大特集 大脳皮質vs.大脳白質

VSRAD^®による大脳皮質および白質体積測定

著者： 松田博史¹

所属機関： ¹国立精神・神経医療研究センター脳病態統合イメージングセンター

ページ範囲：P.487 - P.496

文献概要

脳構造の体積測定は精神・神経疾患の早期診断や鑑別診断，および進行度評価に必須となっている。VSRAD^®は，三次元のMRI T₁強調画像を灰白質，白質に分画し，解剖学的標準化を行いさらに平滑化を行った後に正常データベースと比較することにより個々の症例での灰白質および白質体積を統計学的に評価し，Zスコアを表示する自動解析ソフトウェアである。

参考文献

1) Frisoni GB, Jack CR, Bocchetta M, Bauer C, Frederiksen KS, et al: The EADC-ADNI harmonized protocol for manual hippocampal segmentation on magnetic resonance: evidence of validity. Alzheimers Dement 11: 111-125, 2015

2) Ashburner J, Friston KJ: Voxel-based morphometry: the methods. NeuroImage 11: 805-821, 2000

3) Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, et al: A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage 14: 21-36, 2001

4) Eggert LD, Sommer J, Jansen A, Kircher T, Konrad C: Accuracy and reliability of automated gray matter segmentation pathways on real and simulated structural magnetic resonance images of the human brain. PLOS ONE 7: e45081, 2012

5) Ashburner J: A fast diffeomorphic image registration algorithm. NeuroImage 38: 95-113, 2007

6) Klein A, Andersson J, Ardekani BA, Ashburner J, Avants B, et al: Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration. NeuroImage 46: 786-802, 2009

7) Price S, Paviour D, Scahill R, Stevens J, Rossor M, et al: Voxel-based morphometry detects patterns of atrophy that help differentiate progressive supranuclear palsy and Parkinson's disease. NeuroImage 23: 663-669, 2004

8) Josephs KA, Whitwell JL, Dickson DW, Boeve BF, Knopman DS, et al: Voxel-based morphometry in autopsy proven PSP and CBD. Neurobiol Aging 29: 280-289, 2008

9) Shigemoto Y, Matsuda H, Kamiya K, Maikusa N, Nakata Y, et al: In vivo evaluation of gray and white matter volume loss in the parkinsonian variant of multiple system atrophy using SPM8 plus DARTEL for VBM. Neuroimage Clin 2: 491-496, 2013

10) Hirata Y, Matsuda H, Nemoto K, Ohnishi T, Hirao K, et al: Voxel-based morphometry to discriminate early Alzheimer's disease from controls. Neurosci Lett 382: 269-274, 2005

11) Matsuda H, Mizumura S, Nemoto K, Yamashita F, Imabayashi E, et al: Automatic voxel-based morphometry of structural MRI by SPM8 plus diffeomorphic anatomic registration through exponentiated lie algebra improves the diagnosis of probable Alzheimer Disease. AJNR Am J Neuroradiol 33: 1109-1114, 2012

12) Shibuya Y, Kawakatsu S, Hayashi H, Kobayashi R, Suzuki A, et al: Comparison of entorhinal cortex atrophy between early-onset and late-onset Alzheimer's disease using the VSRAD, a specific and sensitive voxel-based morphometry. Int J Geriatr Psychiatry 28: 372-376, 2013

13) Waragai M, Hata S, Suzuki T, Ishii R, Fujii C, et al: Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. J Alzheimers Dis 41: 1207-1222, 2014

F］florbetapir positron emission tomography and magnetic resonance imaging voxel-based analysis for entorhinal cortex atrophy. Int J Geriatr Psychiatry, 2014 Jul 7 ［Epub ahead of print］

15) Tokuchi R, Hishikawa N, Kurata T, Sato K, Kono S, et al: Clinical and demographic predictors of mild cognitive impairment for converting to Alzheimer's disease and reverting to normal cognition. J Neurol Sci 346: 288-292, 2014

16) Nakatsuka T, Imabayashi E, Matsuda H, Sakakibara R, Inaoka T, et al: Discrimination of dementia with Lewy bodies from Alzheimer's disease using voxel-based morphometry of white matter by statistical parametric mapping 8 plus diffeomorphic anatomic registration through exponentiated Lie algebra. Neuroradiology 55: 559-566, 2013

17) Kantarci K, Ferman TJ, Boeve BF, Weigand SD, Przybelski S, et al: Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies. Neurology 79: 553-560, 2012

18) Hayashi H, Kawakatsu S, Suzuki A, Shibuya Y, Kobayashi R, et al: Application of the VSRAD, a specific and sensitive voxel-based morphometry, to comparison of entorhinal cortex atrophy between dementia with Lewy bodies and Alzheimer's disease. Dement Geriatr Cogn Disord 34: 328-331, 2012

19) Bora E, Fornito A, Pantelis C, Yücel M: Gray matter abnormalities in major depressive disorder: a meta-analysis of voxel based morphometry studies. J Affect Disord 138: 9-18, 2012

20) Niida R, Niida A, Motomura M, Uechi A: Diagnosis of depression by MRI scans with the use of VSRAD—a promising auxiliary means of diagnosis: a report of 10 years research. Int J Gen Med 4: 377-387, 2011

21) Niida A, Niida R, Matsuda H, Inada T, Motomura M, et al: Identification of atrophy of the subgenual anterior cingulate cortex, in particular the subcallosal area, as an effective auxiliary means of diagnosis for major depressive disorder. Int J Gen Med 5: 667-674, 2012