BRAIN and NERVE－神経研究の進歩67巻4号

2015年04月発行

増大特集 大脳皮質vs.大脳白質

白質と脳機能

著者： 和氣弘明¹ 加藤大輔¹

所属機関： ¹自然科学研究機構生理学研究所生体恒常機能発達機構研究部門

ページ範囲：P.505 - P.512

文献概要

オリゴデンドロサイトは軸索周囲に髄鞘を形成することにより，跳躍伝導によって神経伝導速度を50倍まで速めることができる。近年，髄鞘化には神経活動依存性があることが示されている。すなわち神経活動依存的に神経伝導速度を調節することで神経細胞活動の時間的活動を制御することができる。神経細胞活動を時間的に制御することにより脳情報処理を効率化，適正化することができると考えられている。本項ではこのようなオリゴデンドロサイトの脳機能に対する寄与を議論する。

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