BRAIN and NERVE－神経研究の進歩67巻5号

2015年05月発行

総説

記憶の脳回路痕跡

著者： 小島寛人¹ 坂口哲也¹ 池谷裕二¹

所属機関： ¹東京大学大学院薬学系研究科薬品作用教室

ページ範囲：P.599 - P.604

文献概要

記憶はどう保存されて，どう引き出されるのか。これは誰もが抱きうる疑問である。われわれは日々新しい記憶を蓄積させながら，一方で，古い記憶を思い出す。一見，当たり前のように思われるが，われわれの脳はこの過程をどのようにして実現しているのだろうか。この現象の実態に迫る数々の研究がなされている。本稿では，記憶が蓄えられるメカニズムについて，歴史的な背景から最新の知見に至るまで述べていきたい。

参考文献

1) Morris RG: D. O. Hebb: The Organization of Behavior, Wiley: New York; 1949．Brain Res Bull 50: 437, 1999

2) Kandel ER, Tauc L: Mechanism of prolonged heterosynaptic facilitation. Nature 202: 145-147, 1964

3) Scoville WB, Milner B: Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20: 11-21, 1957

4) Bliss TV, Lomo T: Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232: 331-356, 1973

5) Bliss TV, Gardner-Medwin AR: Long-lasting potentiation of synaptic transmission in the dentate area of the unanaestetized rabbit following stimulation of the perforant path. J Physiol 232: 357-374, 1973

6) Schwartzkroin PA, Wester K: Long-lasting facilitation of a synaptic potential following tetanization in the in vitro hippocampal slice. Brain Res 89: 107-119, 1975

7) Malenka RC, Bear MF: LTP and LTD: an embarrassment of riches. Neuron 44: 5-21, 2004

8) Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, et al: Engineering a memory with LTD and LTP. Nature 511: 348-352, 2014

9) Rumpel S, LeDoux J, Zador A, Malinow R: Postsynaptic receptor trafficking underlying a form of associative learning. Science 308: 83-88, 2005

10) Morris R, Anderson E, Lynch G, Baudry M: Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5．Nature 319: 774-776, 1986

11) McHugh T, Blum K, Tsien J, Tonegawa S, Wilson M: Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell 87: 1339-1349, 1996

12) Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, et al: Genetic enhancement of learning and memory in mice. Nature 401: 63-69, 1999

13) Tang Y, Wang H, Feng R, Kyin M, Tsien J: Differential effects of enrichment on learning and memory function in NR2B transgenic mice. Neuropharmacology 41: 779-790, 2001

14) Guzowski JF, McNaughton BL, Barnes CA, Worley PF: Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles. Nat Neurosci 2: 1120-1124, 1999

15) Reijmers LG, Perkins BL, Matsuo N, Mayford M: Localization of a stable neural correlate of associative memory. Science 317: 1230-1233, 2007

16) Han JH, Kushner SA, Yiu AP, Hsiang HL, Buch T, et al: Selective erasure of a fear memory. Science 323: 1492-1496, 2009

17) Zhou Y, Won J, Karlsson MG, Zhou M, Rogerson T, et al: CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala. Nat Neurosci 12: 1438-1443, 2009

18) Liu X, Ramirez S, Pang PT, Puryear CB, Govindarajan A, et al: Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 484: 381-385, 2012

19) Redondo RL, Kim K, Arons AL, Ramirez S, Liu S, et al: Bidirectional reversal of the valence associated with the hippocampal memory engram. Nature 513: 426-430, 2014

20) O'Keefe J: A review of the hippocampal place cells. Prog Neurobiol 13: 419-439, 1979

21) Buzsaki G: Theta oscillations in the hippocampus. Neuron 33: 325-340, 2002

22) Eichenbaum H: A cortical-hippocampal system for declarative memory. Nat Rev Neurosci 1: 41-50, 2000

23) Haist F, Bowden Gore J, Mao H: Consolidation of human memory over decades revealed by functional magnetic resonance imaging. Nat Neurosci 4: 1139-1145, 2001

24) Lee AK, Wilson MA: Memory of sequential experience in the hippocampus during slow wave sleep. Neuron 36: 1183-94, 2002

25) Nakashiba T, Buhl DL, McHugh TJ, Tonegawa S: Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory. Neuron 62: 781-787, 2009

26) Mizunuma M, Norimoto H, Tao K, Egawa T, Hanaoka K, et al: Unbalanced excitability underlies offline reactivation of behaviorally activated neurons. Nat Neurosci 17: 503-505, 2014