BRAIN and NERVE－神経研究の進歩68巻2号

2016年02月発行

特集 筋疾患の認知機能障害

筋強直性ジストロフィー1型の嗅覚障害

著者： 政岡ゆり¹

所属機関： ¹昭和大学医学部生理学部門生体調節機能学

ページ範囲：P.145 - P.150

文献概要

嗅覚情報は視床を介さずに情動を司る辺縁系に直接送られる特徴を持つ。アルツハイマー病，パーキンソン病において扁桃体，海馬を含む辺縁系の異変が，最初に嗅覚異常として認められる理由はそこにある。同時期に情動反応の低下，社会性の欠如が認められることも特徴である。また筋硬直，筋萎縮を特徴とする筋強直性ジストロフィー1型においても最初の徴候として嗅覚異常を認める。本稿では嗅覚レベルの測定法，嗅覚関連部位を把握し脳の異変をすばやく捉えるための基礎を紹介する。

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