BRAIN and NERVE－神経研究の進歩68巻6号

2016年06月発行

特集 脳とフローラ

ADHDモデルラットの情動形成における腸脳連関

著者： 飛田秀樹¹

所属機関： ¹名古屋市立大学医学研究科脳神経生理学

ページ範囲：P.633 - P.639

文献概要

発育期の環境（腸内フローラを含む）が情動行動の形成に関係するかという問いは興味深い。注意欠陥多動障害モデル動物を用い，発育期のうま味刺激が不安様行動や社会性行動の情動行動に与える影響を調べた。その結果，離乳後から成熟期までのうま味摂取が腹部迷走神経を介し脳へ作用し，社会性行動が変化する（攻撃性の減少）ことが示された。腸内細菌の変化や脳内メカニズムなど解決されるべき腸脳連関メカニズムを考察する。

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