BRAIN and NERVE－神経研究の進歩68巻7号

2016年07月発行

増大特集 認知症の危険因子と防御因子

糖尿病と認知症の疫学

著者： 小原知之¹

所属機関： ¹九州大学大学院医学研究院精神病態医学

ページ範囲：P.719 - P.727

文献概要

日本人における糖尿病と認知症発症の関係を明らかにするために，1988年の久山町健診を受診した認知症のない高齢住民全員に75g経口糖負荷試験を実施して耐糖能レベルを正確に評価し，15年間前向きに追跡した。多変量解析でその他の危険因子を調整した結果，糖尿病は認知症，特にアルツハイマー病発症の有意な危険因子であった。認知症の社会的負担を軽減するうえで，増え続ける糖尿病の予防と適切な管理が重要と考えられる。

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