BRAIN and NERVE－神経研究の進歩68巻7号

2016年07月発行

増大特集 認知症の危険因子と防御因子

アルツハイマー病予防と摂取栄養素

著者： 大塚美恵子¹

所属機関： ¹国際医療福祉大学病院神経内科

ページ範囲：P.809 - P.817

文献概要

アルツハイマー病（AD）発症予防のためには，地中海型食事パターンや従来の和食を基本に野菜，魚を中心とした食事パターンが重要である。一方，ビタミンE，葉酸など単品での介入は，それらが欠乏していれば認知機能低下の予防につながる可能性が出てきた。また，ドコサヘキサエン酸はAD発症の1次あるいは2次予防として期待される。さらに，AD脳内ではインスリンシグナル伝達障害が明らかとなり，ブドウ糖以外の脳のエネルギーとして，中鎖脂肪酸の効果も期待される。

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