BRAIN and NERVE－神経研究の進歩68巻7号

2016年07月発行

増大特集 認知症の危険因子と防御因子

認知症の危険因子と環境要因

著者： 田代善崇¹² 木下彩栄¹²

所属機関： ¹京都大学大学院医学研究科人間健康科学系専攻 ²京都大学大学院医学研究科メディカルイノベーションセンターSKプロジェクト

ページ範囲：P.837 - P.847

文献概要

昨今の画像診断技術・バイオマーカーの開発により，アルツハイマー病のpreclinical stageからの経過が明らかになってきた。発症20年以上前から脳内にアミロイドβが沈着し，その広がりとともに，神経原線維変化が大脳新皮質へと出現して認知機能低下を引き起こす。この過程を抑制することが，アルツハイマー病の病態制御につながるが，現時点では，疫学的研究から明らかにされた環境要因への介入が最も現実的な手段であり，効果も大きいと考えられる。

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