BRAIN and NERVE－神経研究の進歩68巻7号

2016年07月発行

増大特集 認知症の危険因子と防御因子

頭部外傷の遅発性後遺症—慢性外傷性脳症（CTE）と頭部外傷に続発するアルツハイマー病を中心に

著者： 高畑圭輔¹² 田渕肇² 三村將²

所属機関： ¹国立研究開発法人放射線医学総合研究所臨床研究クラスタ脳機能イメージング研究部 ²慶應義塾大学医学部精神・神経科

ページ範囲：P.849 - P.857

文献概要

頭部への打撃から数年〜数十年の年月を経て，認知機能低下や精神症状，運動症状などの症候が遅れて出現することがある。こうした遅発性の症候に，外傷を契機とする神経変性が関与していると考えられている。本総説では，頭部外傷によって引き起こされる遅発性後遺症について概説する。特に近年問題となっている慢性外傷性脳症，および頭部外傷に続発するアルツハイマー病について重点的に述べる。また早期診断法としてのタウ・アミロイドPETや予防的介入の可能性についても述べる。

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