BRAIN and NERVE－神経研究の進歩68巻8号

2016年08月発行

特集 こころと汗

発汗の脳機能画像

著者： 小島一歩¹ 平野成樹¹

所属機関： ¹千葉大学大学院医学研究院神経内科学

ページ範囲：P.903 - P.909

文献概要

ヒトにおける温熱性および精神性発汗の中枢機構について機能的MRIを用いた画像研究を中心に概説する。温熱性発汗においては視床下部（視索前野）での活動を認め，精神性発汗では前頭前野や島皮質，前部帯状回が関与していることが報告されている。温熱性および精神性発汗の共通する中枢として中脳背側および延髄外側部が挙げられる。発汗の中枢性機構は交感神経活動のみならず，情動や内的感覚，注意覚醒をも包括している。

参考文献

1)Ogawa S, Lee TM, Kay AR, Tank DW: Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 87: 9868-9872, 1990

2)平野成樹, 山田真希子: 神経画像のネットワーク解析. Brain Nerve 65: 659-667, 2013

3)朝比奈正人: 発汗の神経学. Brain Nerve 67: 605-616, 2015

4)LeDoux JE, Damasio A: Emotions and feelings. Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, et al (eds): Principles of Neural Science. 5th edition. McGraw-Hill, NewYork, 2013, pp1079-1094

5)Shibasaki M, Crandall CG: Mechanisms and controllers of eccrine sweating in humans. Front Biosci 2: 685-696, 2010

6)Nakayama T, Eisenman JS, Hardy JD: Single unit activity of anterior hypothalamus during local heating. Science 134: 560-561, 1961

7)Nakamura K, Morrison SF: A thermosensory pathway that controls body temperature. Nat Neurosci 11: 62-71, 2008

8)Morrison SF, Nakamura K: Central neural pathways for thermoregulation. Front Biosci (Landmark Ed) 16: 74-104, 2011

9)齋藤　博: 温熱性発汗の中枢路に関する機能解剖的側面. 発汗学20: 65-68, 2013

10)Farrell MJ, Trevaks D, Taylor NAS, McAllen RM: Brain stem representation of thermal and psychogenic sweating in humans. Am J Physiol Regul Integr Comp Physiol 304: R810-R817, 2013

11)Farrell MJ, Trevaks D, McAllen RM: Preoptic activation and connectivity during thermal sweating in humans. Temperature 1: 135-141, 2014

12)Farrell MJ, Trevaks D, Taylor NA, McAllen RM: Regional brain responses associated with thermogenic and psychogenic sweating events in humans. J Neurophysiol 114: 2578-2587, 2015

13)朝比奈正人, 山中義崇, 赤荻悠一, 福島剛志, 藤沼好克, 他: 精神性発汗の中枢路—主に神経疾患における所見からの推察. 発汗学18: 12-14, 2011

14)Asahina M, Suzuki A, Mori M, Kanesaka T, Hattori T: Emotional sweating response in a patient with bilateral amygdala damage. Int J Psychophysiol 47: 87-93, 2003

15)Mangina CA, Beuzeron-Mangina JH: Direct electrical stimulation of specific human brain structures and bilateral electrodermal activity. Int J Psychophysiol 22: 1-8, 1996

16)Asahina M, Sakakibara R, Liu Z, Ito T, Yamanaka Y, et al: The raphe magnus/pallidus regulates sweat secretion and skin vasodilation of the cat forepaw pad: a preliminary electrical stimulation study. Neurosci Let 415: 283-287, 2007

17)Fredrikson M, Furmark T, Olsson MT, Fischer H, Andersson J, et al: Functional neuroanatomical correlates of electrodermal activity: a positron emission tomographic study. Psychophysiology 35: 179-185, 1998

18)Williams LM, Brammer MJ, Skerrett D, Lagopolous J, Rennie C, et al: The neural correlates of orienting: an integration of fMRI and skin conductance orienting. Neuroreport 11: 3011-3015, 2000

19)Critchley HD, Elliott R, Mathias CJ, Dolan RJ: Neural activity relating to generation and representation of galvanic skin conductance responses: a functional magnetic resonance imaging study. J Neurosci 20: 3033-3040, 2000

20)Patterson JC 2nd, Ungerleider LG, Bandettini PA: Task-independent functional brain activity correlation with skin conductance changes: an fMRI study. NeuroImage 17: 1797-1806, 2002

21)James C, Henderson L, Macefield VG: Real-time imaging of brain areas involved in the generation of spontaneous skin sympathetic nerve activity at rest. NeuroImage 74: 188-194, 2013

22)Macefield VG, James C, Henderson LA: Identification of sites of sympathetic outflow at rest and during emotional arousal: concurrent recordings of sympathetic nerve activity and fMRI of the brain. Int J Psychophysiol 89: 451-459, 2013

23)Henderson LA, Stathis A, James C, Brown R, McDonald S, et al: Real-time imaging of cortical areas involved in the generation of increases in skin sympathetic nerve activity when viewing emotionally charged images. NeuroImage 62: 30-40, 2012