BRAIN and NERVE－神経研究の進歩69巻10号

2017年10月発行

特集 成人てんかん—知っておきたい6つのトピック

てんかんと自己免疫

著者： 松本理器¹ 坂本光弘¹ 池田昭夫²

所属機関： ¹京都大学大学院医学研究科臨床神経学 ²京都大学大学院医学研究科てんかん・運動異常生理学講座

ページ範囲：P.1115 - P.1124

文献概要

神経細胞表面・細胞外の抗原を標的とする自己抗体が関与する自己免疫性てんかんは，その多くがてんかんを主徴の1つないし唯一の症状とする自己免疫性（辺縁系）脳炎の不全型に位置づけられる。亜急性に出現する特徴的なてんかん発作に加え，解剖・機能画像，脳脊髄液検査，脳波で中枢神経の炎症が示唆されれば，抗体結果を待たずに発症早期の免疫療法開始が望まれる。炎症マーカーの確立が非典型例（軽症，くすぶり型）の免疫治療戦略の策定には重要である。

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