BRAIN and NERVE－神経研究の進歩69巻11号

2017年11月発行

増大特集 こころの時間学の未来

過去の学習記憶を未来の適応行動に活かす神経機構

著者： 小川正晃¹

所属機関： ¹京都大学大学院医学研究科高次脳科学講座神経生物学分野

ページ範囲：P.1241 - P.1250

文献概要

われわれは常に，さまざまな外的・内的状況に対し過去の学習記憶をもとに適切に行動する必要がある。この種の意思決定に重要なのが大脳連合野の前頭眼窩野（OFC）である。本論は，不確実な報酬の情報処理に関するOFC機能を例に，現在想定されているOFCの役割について概説する。さらにOFCを含む神経回路が状況特異的，かつタイミング特異的な意思決定に果たす因果的役割を解明する重要性，およびそのために必要な方法論について論じる。

参考文献

1)Stalnaker TA, Cooch NK, Schoenbaum G: What the orbitofrontal cortex does not do. Nat Neurosci 18: 620-627, 2015

2)Bechara A, Damasio AR, Damasio H, Anderson SW: Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50: 7-15, 1994

3)Clark L, Bechara A, Damasio H, Aitken MR, Sahakian BJ, et al: Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making. Brain 131: 1311-1322, 2008

4)Mobini S, Body S, Ho MY, Bradshaw CM, Szabadi E, et al: Effects of lesions of the orbitofrontal cortex on sensitivity to delayed and probabilistic reinforcement. Psychopharmacology (Berl) 160: 290-298, 2002

5)Ishii H, Ohara S, Tobler PN, Tsutsui K, Iijima T: Inactivating anterior insular cortex reduces risk taking. J Neurosci 32: 16031-16039, 2012

6)Hsu M, Bhatt M, Adolphs R, Tranel D, Camerer CF: Neural systems responding to degrees of uncertainty in human decision-making. Science 310: 1680-1683, 2005

7)Kepecs A, Uchida N, Zariwala HA, Mainen ZF: Neural correlates, computation and behavioural impact of decision confidence. Nature 455: 227-231, 2008

8)O'Neill M, Schultz W: Coding of reward risk by orbitofrontal neurons is mostly distinct from coding of reward value. Neuron 68: 789-800, 2010

9)Pearce JM, Hall G: A model for Pavlovian learning: variations in the effectiveness of conditioned but not of unconditioned stimuli. Psychol Rev 87: 532-552, 1980

10)Mackintosh NJ: A theory of attention: variations in the associability of stimuli with reinforcement. Psychol Rev 82: 276-298, 1975

11)Ogawa M, van der Meer MA, Esber GR, Cerri DH, Stalnaker TA, et al: Risk-responsive orbitofrontal neurons track acquired salience. Neuron 77: 251-258, 2013

12)Esber GR, Haselgrove M: Reconciling the influence of predictiveness and uncertainty on stimulus salience: a model of attention in associative learning. Proc Biol Sci 278: 2553-2561, 2011

13)Monosov IE, Leopold DA, Hikosaka O: Neurons in the primate medial basal forebrain signal combined information about reward uncertainty, value, and punishment anticipation. J Neurosci 35: 7443-7459, 2015

14)White JK, Monosov IE: Neurons in the primate dorsal striatum signal the uncertainty of object-reward associations. Nature Communications 7: 1-8, 2016

15)Collins L, Young DB, Davies K, Pearce JM: The influence of partial reinforcement on serial autoshaping with pigeons. Q J Exp Psychol B 35: 275-290, 1983

16)Konorski J: Integrative activity of the brain: an interdisciplinary approach. University of Chicago Press, Chicago, 1967

17)Papini MR, Wood M, Daniel AM, Norris JN: Reward loss as psychological pain. Int J Psychol Psychol Ther 6: 189-213, 2006

18)Feierstein CE, Quirk MC, Uchida N, Sosulski DL, Mainen ZF: Representation of spatial goals in rat orbitofrontal cortex. Neuron 51: 495-507, 2006

19)Furuyashiki T, Holland PC, Gallagher M: Rat orbitofrontal cortex separately encodes response and outcome information during performance of goal-directed behavior. J Neurosci 28: 5127-5138, 2008

20)McDannald MA, Esber GR, Wegener MA, Wied HM, Liu TL, et al: Orbitofrontal neurons acquire responses to ‘valueless’ Pavlovian cues during unblocking. Elife 3: e02653, 2014［doi: 10.7554/eLife.02653］

21)Bechara A, Damasio AR, Damasio H, Anderson SW: Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50: 7-15, 1994

22)Damasio AR, Tranel D, Damasio HC: Ch. 11. Somatic markers and the guidance of behavior: theory and preliminary testing. Levin HS, Eisenberg HM, Benton AL (eds): Frontal Lobe Function and Dysfunction. Oxford University Press, New York, 1991, pp217-229

23)Gallagher M, McMahan RW, Schoenbaum G: Orbitofrontal cortex and representation of incentive value in associative learning. J Neurosci 19: 6610-6614, 1999

24)Rudebeck PH, Saunders RC, Prescott AT, Chau LS, Murray EA: Prefrontal mechanisms of behavioral flexibility, emotion regulation and value updating. Nat Neurosci 16: 1140-1145, 2013

25)Schoenbaum G, Roesch MR, Stalnaker TA: Orbitofrontal cortex, decision-making and drug addiction. Trends Neurosci 29: 116-124, 2006

26)Wilson RC, Takahashi YK, Schoenbaum G, Niv Y: Orbitofrontal cortex as a cognitive map of task space. Neuron 81: 267-279, 2014

27)Takahashi YK, Roesch MR, Wilson RC, Toreson K, O'Donnell P, et al: Expectancy-related changes in firing of dopamine neurons depend on orbitofrontal cortex. Nat Neurosci 14: 1590-1597, 2011

28)Schuck NW, Cai MB, Wilson RC, Niv Y: Human orbitofrontal cortex represents a cognitive map of state space. Neuron 91: 1402-1412, 2016

29)Schoenbaum G, Roesch MR, Stalnaker TA, Takahashi YK: A new perspective on the role of the orbitofrontal cortex in adaptive behaviour. Nat Rev Neurosci 10: 885-892, 2009

30)Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, et al: Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci 17: 1123-1129, 2014

31)Burguière E, Monteiro P, Feng G, Graybiel AM: Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science 340: 1243-1246, 2013