BRAIN and NERVE－神経研究の進歩69巻3号

2017年03月発行

特集 磁気刺激の新たな展開

神経ネットワークダイナミクスから探る反復経頭蓋磁気刺激の抗うつ効果

著者： 中村元昭¹²³

所属機関： ¹神奈川県立精神医療センター ²昭和大学発達障害医療研究所 ³国際電気通信基礎技術研究所脳情報通信総合研究所

ページ範囲：P.247 - P.256

文献概要

反復経頭蓋磁気刺激（rTMS）の作用機序は不明な点も多く，刺激効果は個人差が大きく，最適な刺激法が確立されたとは言いがたい。うつ病rTMSの治療反応性は3〜4割であり，rTMSの最適化と個別化が今後の課題である。課題解決のためにはrTMSの効果を予測する脳指標，rTMSの介入効果を測る脳指標，rTMSをガイドする脳指標などの開発が重要である。安静時機能的MRIと脳波を用いて神経ネットワークの観点からうつ病rTMSのバイオマーカーを検討した。

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