BRAIN and NERVE－神経研究の進歩69巻5号

2017年05月発行

特集 Voxel-Based Morphometry—体積からわかること

統合失調症におけるVBM研究

著者： 根本清貴¹

所属機関： ¹筑波大学医学医療系精神医学

ページ範囲：P.513 - P.518

文献概要

脳画像研究により，統合失調症の脳構造に対する理解は飛躍的に増大した。Voxel-based morphometryは統合失調症研究にも応用され，さまざまな知見が蓄積している。統合失調症では，前頭葉，側頭葉，辺縁系における容積低下，そして辺縁系における容積増加が認められる。これらは発症初期から認められ，病状の進行に伴い萎縮の範囲が広がっていく。これらの知見をどう臨床に還元するかが今後の課題である。

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