BRAIN and NERVE－神経研究の進歩69巻6号

2017年06月発行

特集 局在病変の神経心理学

時刻表的行動—時間，行動，認知機能

著者： 二村明徳¹ 四郎丸あずさ¹ 黒田岳志¹ 本間元康¹² 金野竜太¹ 小野賢二郎¹ 河村満¹³

所属機関： ¹昭和大学内科学講座神経内科学部門 ²杏林大学医学部細胞生理学教室 ³奥沢病院

ページ範囲：P.639 - P.649

文献概要

われわれの概日リズムは視床下部視交叉上核が中枢となり，約24時間の睡眠，覚醒，血圧，体温，ホルモン分泌などの生理機能のリズムを生成している。時計遺伝子の解明は，時計遺伝子がわれわれの情動や認知および行動においても重要な役割を果たしていることを明らかにしつつある。アルツハイマー病や加齢によって概日リズムの同調関係は徐々に崩壊し，睡眠障害や情動，認知機能に影響している。現代社会においてはシフト勤務に従事している人も多いが，シフト勤務疾患や肥満との関連も指摘されている。前頭側頭型認知症や前頭葉や側頭葉病変で時刻表的生活を呈する患者がいる。強迫性障害と比較し，その神経基盤を概観する。

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