BRAIN and NERVE－神経研究の進歩69巻7号

2017年07月発行

増大特集 あしたのアルツハイマー病治療

MRI解析の進歩

著者： 松田博史¹

所属機関： ¹国立精神・神経医療研究センター脳病態統合イメージングセンター

ページ範囲：P.799 - P.807

文献概要

アルツハイマー病においてMRIは早期診断，鑑別診断，および進行度評価に必須の検査法となっている。構造評価においては，視覚に頼らないコンピュータによる萎縮の自動診断が日常臨床で可能である。さらに内側側頭部の亜区域体積測定や精度の高い縦断体積測定が可能となり，治験におけるサンプルサイズの算出などに役立つ。また，局所的な萎縮を捉えるばかりでなく，グラフ理論により脳内ネットワークを評価することができる。

参考文献

1)Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, et al: Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7: 257-262, 2011

2)Frisoni GB, Fox NC, Jack CR Jr, Scheltens P, Thompson PM: The clinical use of structural MRI in Alzheimer disease. Nat Rev Neurol 6: 67-77, 2010

F］AV-1451 tau PET imaging results with cortical atrophy and symptoms in typical and atypical Alzheimer disease. JAMA Neurol 74: 427-436, 2017

4)Fischl B, Salat DH, Busa E, Albert M, Dieterich M, et al: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33: 341-355, 2002

5)Tustison NJ, Cook PA, Klein A, Song G, Das SR, et al: Large-scale evaluation of ANTs and FreeSurfer cortical thickness measurements. NeuroImage 99: 166-179, 2014

6)Fujishima M, Maikusa N, Nakamura K, Nakatsuka M, Matsuda H, et al: Mild cognitive impairment, poor episodic memory, and late-life depression are associated with cerebral cortical thinning and increased white matter hyperintensities. Front Aging Neurosci 6: 306, 2014

7)Ashburner J, Friston KJ: Voxel-based morphometry--the methods. NeuroImage 11: 805-821, 2000

8)Hirata Y, Matsuda H, Nemoto K, Ohnishi T, Hirao K, et al: Voxel-based morphometry to discriminate early Alzheimer's disease from controls. Neurosci Lett 382: 269-274, 2005

9)Matsuda H, Mizumura S, Nemoto K, Yamashita F, Imabayashi E, et al: Automatic voxel-based morphometry of structural MRI by SPM8 plus diffeomorphic anatomic registration through exponentiated lie algebra improves the diagnosis of probable Alzheimer disease. AJNR Am J Neuroradiol 33: 1109-1114, 2012

10)Whitwell JL, Weigand SD, Shiung MM, Boeve BF, Ferman TJ, et al: Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease. Brain 130: 708-719, 2007

11)Kantarci K, Ferman TJ, Boeve BF, Weigand SD, Przybelski S, et al: Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies. Neurology 79: 553-560, 2012

12)Nakatsuka T, Imabayashi E, Matsuda H, Sakakibara R, Inaoka T, et al: Discrimination of dementia with Lewy bodies from Alzheimer's disease using voxel-based morphometry of white matter by statistical parametric mapping 8 plus diffeomorphic anatomic registration through exponentiated Lie algebra. Neuroradiology 55: 559-566, 2013

13)Ohnishi T, Matsuda H, Tabira T, Asada T, Uno M: Changes in brain morphology in Alzheimer disease and normal aging: is Alzheimer disease an exaggerated aging process? AJNR Am J Neuroradiol 22: 1680-1685, 2001

14)Matsuda H: Voxel-based morphometry of brain MRI in normal aging and Alzheimer's disease. Aging Dis 4: 29-37, 2013

15)Risacher SL, Shen L, West JD, Kim S, McDonald BC, et al: Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort. Neurobiol Aging 31: 1401-1418, 2010

16)Holland D, McEvoy LK, Dale AM; Alzheimer's Disease Neuroimaging Initiative: Unbiased comparison of sample size estimates from longitudinal structural measures in ADNI. Hum Brain Mapp 33: 2586-2602, 2012

17)Fujishima M, Kawaguchi A, Maikusa N, Kuwano R, Iwatsubo T, et al: Sample size estimation for Alzheimer's disease trials from Japanese ADNI serial magnetic resonance imaging. J Alzheimers Dis 56: 75-88, 2017

18)Freeborough PA, Fox NC: The boundary shift integral: an accurate and robust measure of cerebral volume changes from registered repeat MRI. IEEE Trans Med Imaging 16: 623-629, 1997

19)Wang H, Yushkevich PA: Multi-atlas segmentation with joint label fusion and corrective learning-an open source implementation. Front Neuroinform 7: 27, 2013

20)Gómez-Isla T, Price JL, McKeel DW Jr, Morris JC, Growdon JH, et al: Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 16: 4491-4500, 1996

21)Yushkevich PA, Pluta JB, Wang H, Xie L, Ding SL, et al: Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment. Hum Brain Mapp 36: 258-287, 2015

22)Iglesias JE, Augustinack JC, Nguyen K, Player CM, Player A, et al: A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: application to adaptive segmentation of in vivo MRI. NeuroImage 115: 117-137, 2015

23)Bullmore ET, Bassett DS: Brain graphs: graphical models of the human brain connectome. Annu Rev Clin Psychol 7: 113-140, 2011

24)Rokicki J, Li L, Imabayashi E, Kaneko J, Hisatsune T, et al: Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults. Front Aging Neurosci 7: 219, 2015

25)Hosseini SM, Hoeft F, Kesler SR: GAT: a graph-theoretical analysis toolbox for analyzing between-group differences in large-scale structural and functional brain networks. PLOS ONE 7: e40709, 2012

26)Sone D, Matsuda H, Ota M, Maikusa N, Kimura Y, et al: Graph theoretical analysis of structural neuroimaging in temporal lobe epilepsy with and without psychosis. PLOS ONE 11: e0158728, 2016

27)Tijms BM, Wink AM, de Haan W, van der Flier WM, Stam CJ, et al: Alzheimer's disease: connecting findings from graph theoretical studies of brain networks. Neurobiol Aging 34: 2023-2036, 2013

28)He Y, Chen Z, Evans A: Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer's disease. J Neurosci 28: 4756-4766, 2008

29)Phillips DJ, McGlaughlin A, Ruth D, Jager LR, Soldan A, et al: Graph theoretic analysis of structural connectivity across the spectrum of Alzheimer's disease: the importance of graph creation methods. Neuroimage Clin 7: 377-390, 2015

30)Wang L, Zang Y, He Y, Liang M, Zhang X, et al: Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI. NeuroImage 31: 496-504, 2006

31)Supekar K, Menon V, Rubin D, Musen M, Greicius MD: Network analysis of intrinsic functional brain connectivity in Alzheimer's disease. PLOS Comput Biol 4: e1000100, 2008

32)Li Y, Qin Y, Chen X, Li W: Exploring the functional brain network of Alzheimer's disease: based on the computational experiment. PLOS ONE 8: e73186, 2013

33)Chen G, Zhang HY, Xie C, Chen G, Zhang ZJ, et al: Modular reorganization of brain resting state networks and its independent validation in Alzheimer's disease patients. Front Hum Neurosci 7: 456, 2013

34)Khazaee A, Ebrahimzadeh A, Babajani-Feremi A: Identifying patients with Alzheimer's disease using resting-state fMRI and graph theory. Clin Neurophysiol 126: 2132-2141, 2015

35)Tijms BM, Seriès P, Willshaw DJ, Lawrie SM: Similarity-based extraction of individual networks from gray matter MRI scans. Cereb Cortex 22: 1530-1541, 2012