BRAIN and NERVE－神経研究の進歩69巻8号

2017年08月発行

総説

グルテン失調症—新たなバイオマーカーとしての抗トランスグルタミナーゼ6抗体

著者： 佐藤健治¹ 南里和紀²³

所属機関： ¹浴風会病院神経内科 ²東大和病院神経内科 ³東京医科大学八王子医療センター神経内科

ページ範囲：P.933 - P.940

文献概要

グルテン関連疾患（GRD）はグルテン摂取という共通のトリガーを持つ多様な臨床症状を呈する疾患である。近年，セリアック病やグルテン失調症などのGRDの報告が本邦でも散見するようになり，その存在が認識されつつある。グルテン失調症は抗グリアジン抗体陽性の特発性孤発性運動失調症と定義され，最近，その診断における抗トランスグルタミナーゼ6（TG6）抗体の有用性が報告された。本総説では，グルテン失調症を概説し，自験例の抗TG6抗体陽性グルテン失調症を提示した。

参考文献

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