BRAIN and NERVE－神経研究の進歩70巻1号

2018年01月発行

特集 筋痛性脳脊髄炎／慢性疲労症候群の今

【特別寄稿】筋痛性脳脊髄炎／慢性疲労症候群における神経学的異常

著者： コマロフアンソニー¹ 高橋良輔² 山村隆³ 澤村正典²

所属機関： ¹ハーバード大学医学部ブリガムアンドウィメンズ病院内科 ²京都大学大学院医学研究科脳病態生理学講座臨床神経学（神経内科） ³国立精神・神経医療研究センター神経研究所免疫研究部

ページ範囲：P.41 - P.54

文献概要

筋痛性脳脊髄炎／慢性疲労症候群（ME/CFS）は6カ月以上持続する疲労感，睡眠障害，認知機能障害などを生じる疾患である。ME/CFSは自覚症状により定義されているため疾患概念そのものに対する懐疑的意見もあるが，近年の研究では神経画像，血液マーカーの解析，代謝，ミトコンドリアなどの研究でさまざまな客観的な異常が報告されている。特に脳内外での免疫系の活性化がきっかけとなり，炎症性サイトカインが放出されることで病気が発症する可能性が指摘されている。この総説ではME/CFSについての客観的なエビデンスを中心に解説する。

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