BRAIN and NERVE－神経研究の進歩70巻11号

2018年11月発行

増大特集 脳科学で解き明かす精神神経症候

作話とエピソード記憶における「時間」と「自己」

著者： 岩田沙恵子¹² 月浦崇¹

所属機関： ¹京都大学大学院人間・環境学研究科認知・行動科学講座認知科学分野 ²日本学術振興会

ページ範囲：P.1203 - P.1208

文献概要

作話とは，実際にはなかったことをあったかのように話す症候であり，前脳基底部損傷による健忘例でしばしば観察される。エピソード記憶における「時間」と「自己」の処理には，前脳基底部，内側前頭前皮質，海馬の間のネットワークが重要であり，そのうち前脳基底部は自己を時間軸の中で適切に定位するインターフェースの役割を担っている。前脳基底部性健忘における作話は，前脳基底部のこのような機能の低下を反映している可能性がある。

参考文献

1)穴水幸子, 三村　將: 作話の神経機構. Brain Med 19: 165-172, 2007

2)Schacter DL, Norman KA, Koutstaal W: The cognitive neuroscience of constructive memory. Annu Rev Psychol 49: 289-318, 1998

3)Turner MS, Cipolotti L, Yousry TA, Shallice T: Confabulation: damage to a specific inferior medial prefrontal system. Cortex 44: 637-648, 2008

4)Turner MS, Cipolotti L, Shallice T: Spontaneous confabulation, temporal context confusion and reality monitoring: a study of three patients with anterior communicating artery aneurysms. J Int Neuropsychol Soc 16: 984-994, 2010

5)Dalla Barba G, Cappelletti JY, Signorini M, Denes G: Confabulation: remembering ‘another’ past, planning ‘another’ future. Neurocase 3: 425-436, 1997

6)Zannino GD, Barban F, Caltagirone C, Carlesimo GA: Do confabulators really try to remember when they confabulate? A case report. Cogn Neuropsychol 25: 831-852, 2008

7)Damasio AR, Graff-Radford NR, Eslinger PJ, Damasio H, Kassell N: Amnesia following basal forebrain lesions. Arch Neurol 42: 263-271, 1985

8)Alexander MP, Freedman M: Amnesia after anterior communicating artery aneurysm rupture. Neurology 34: 752-757, 1984

9)Dalla Barba G: Memory, Consciousness and Temporality. Springer, New York, 2002

10)Dalla Barba G, Boissé MF: Temporal consciousness and confabulation: is the medial temporal lobe “temporal”? Cogn Neuropsychiatry 15: 95-117, 2010

11)Schnider A, von Däniken C, Gutbrod K: The mechanisms of spontaneous and provoked confabulations. Brain 119: 1365-1375, 1996

12)Dalla Barba G, La Corte V: The hippocampus, a time machine that makes errors. Trends Cogn Sci 17: 102-104, 2013

13)Dalla Barba G: Confabulation: knowledge and recollective experience. Cogn Neuropsychol 10: 1-20, 1993

14)岩田沙恵子, 月浦　崇: エピソード記憶における時間情報の処理に関連する神経基盤とその障害. Brain Nerve 69: 1303-1309, 2017

15)月浦　崇: 記憶における時間文脈の処理を担う脳内機構とその障害. 神経治療学32: 373-377, 2015

16)Tranel D, Jones RD: Knowing “what” and knowing “when”. J Clin Exp Neuropsychol 28: 43-66, 2006

17)Schnider A, Ptak R: Spontaneous confabulators fail to suppress currently irrelevant memory traces. Nat Neurosci 2: 677-681, 1999

18)Schnider A, Ptak R, von Däniken C, Remonda L: Recovery from spontaneous confabulations parallels recovery of temporal confusion in memory. Neurology 55: 74-83, 2000

19)Fujii T, Okuda J, Tsukiura T, Ohtake H, Miura R, et al: The role of the basal forebrain in episodic memory retrieval: a positron emission tomography study. NeuroImage 15: 501-508, 2002

20)Schnider A, Treyer V, Buck A: Selection of currently relevant memories by the human posterior medial orbitofrontal cortex. J Neurosci 20: 5880-5884, 2000

21)Nahum L, Ptak R, Leemann B, Schnider A: Disorientation, confabulation, and extinction capacity: clues on how the brain creates reality. Biol Psychiatry 65: 966-972, 2009

22)Shingaki H, Park P, Ueda K, Murai T, Tsukiura T: Disturbance of time orientation, attention, and verbal memory in amnesic patients with confabulation. J Clin Exp Neuropsychol 38: 171-182, 2016

23)Schnider A: The Confabulating Mind: How the Brain Creates Reality. 2nd edition. Oxford University Press, New York, 2018

24)橋本竜作, 平山和美, 藤井俊勝, 山鳥　重: 過去の二重感と, 過去への往復現象を示した視床下部胚細胞腫の1例. 脳神経55: 257-263, 2003

25)Kuroda T, Futamura A, Sugimoto A, Midorikawa A, Honma M, et al: Autobiographical age awareness disturbance syndrome in autoimmune limbic encephalitis: two case reports. BMC Neurol 15: 238, 2015［doi: 10.1186/s12883-015-0498-7］

26)Borsutzky S, Fujiwara E, Brand M, Markowitsch HJ: Susceptibility to false memories in patients with ACoA aneurysm. Neuropsychologia 48: 2811-2823, 2010

27)Ciaramelli E, Ghetti S, Borsotti M: Divided attention during retrieval suppresses false recognition in confabulation. Cortex 45: 141-153, 2009

28)Ciaramelli E, Ghetti S, Frattarelli M, Làdavas E: When true memory availability promotes false memory: evidence from confabulating patients. Neuropsychologia 44: 1866-1877, 2006

29)Gilboa A, Alain C, Stuss DT, Melo B, Miller S, et al: Mechanisms of spontaneous confabulations: a strategic retrieval account. Brain 129: 1399-1414, 2006

30)Deese J: On the prediction of occurrence of particular verbal intrusions in immediate recall. J Exp Psychol 58: 17-22, 1959

31)Roediger HL, McDermott KB: Creating false memories: remembering words not presented in lists. J Exp Psychol Learn Mem Cogn 21: 803-814, 1995

32)Philippi CL, Duff MC, Denburg NL, Tranel D, Rudrauf D: Medial PFC damage abolishes the self-reference effect. J Cogn Neurosci 24: 475-481, 2012

33)Gilboa A: Autobiographical and episodic memory--one and the same? Evidence from prefrontal activation in neuroimaging studies. Neuropsychologia 42: 1336-1349, 2004

34)Yamawaki R, Nakamura K, Aso T, Shigemune Y, Fukuyama H, et al: Remembering my friends: medial prefrontal and hippocampal contributions to the self-reference effect on face memories in a social context. Hum Brain Mapp 38: 4256-4269, 2017

35)Macrae CN, Moran JM, Heatherton TF, Banfield JF, Kelley WM: Medial prefrontal activity predicts memory for self. Cereb Cortex 14: 647-654, 2004

36)Cabeza R, St Jacques P: Functional neuroimaging of autobiographical memory. Trends Cogn Sci 11: 219-227, 2007

37)Schmitz TW, Johnson SC: Relevance to self: A brief review and framework of neural systems underlying appraisal. Neurosci Biobehav Rev 31: 585-596, 2007

38)Davachi L: Item, context and relational episodic encoding in humans. Curr Opin Neurobiol 16: 693-700, 2006

39)Diana RA, Yonelinas AP, Ranganath C: Imaging recollection and familiarity in the medial temporal lobe: a three-component model. Trends Cogn Sci 11: 379-386, 2007

40)月浦　崇: 脳機能画像研究からみたエピソード記憶の神経基盤—側頭葉内側面における機能解離. Brain Nerve 60: 833-844, 2008

41)Mesulam MM, Mufson EJ, Levey AI, Wainer BH: Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey. J Comp Neurol 214: 170-197, 1983

42)Gray TS: Functional and anatomical relationships among the amygdala, basal forebrain, ventral striatum, and cortex. An integrative discussion. Ann N Y Acad Sci 877: 439-444, 1999

43)Friston KJ: Functional and effective connectivity in neuroimaging: a synthesis. Hum Brain Mapp 2: 56-78, 1994

44)Li K, Guo L, Nie J, Li G, Liu T: Review of methods for functional brain connectivity detection using fMRI. Comput Med Imaging Graph 33: 131-139, 2009

45)Rogers BP, Morgan VL, Newton AT, Gore JC: Assessing functional connectivity in the human brain by fMRI. Magn Reson Imaging 25: 1347-1357, 2007

46)Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, et al: Psychophysiological and modulatory interactions in neuroimaging. NeuroImage 6: 218-229, 1997

47)McLaren DG, Ries ML, Xu G, Johnson SC: A generalized form of context-dependent psychophysiological interactions (gPPI): a comparison to standard approaches. Neuroimage 61: 1277-1286, 2012

48)Friston KJ, Harrison L, Penny W: Dynamic causal modelling. NeuroImage 19: 1273-1302, 2003

49)Friston KJ, Preller KH, Mathys C, Cagnan H, Heinzle J, et al: Dynamic causal modelling revisited. NeuroImage 2017 Feb 17 [Epub ahead of print]

50)月浦　崇: 記憶の神経基盤解明のための複合的アプローチ—非侵襲的脳機能画像法と神経心理学的方法. 高次脳機能研究24: 129-138, 2004