BRAIN and NERVE－神経研究の進歩70巻2号

2018年02月発行

特集 知っておきたい神経感染症

ジカウイルスとギラン・バレー症候群

著者： 小池春樹¹

所属機関： ¹名古屋大学大学院医学系研究科神経内科

ページ範囲：P.113 - P.120

文献概要

近年，ジカ熱の世界的な流行に伴いジカウイルスとギラン・バレー症候群（GBS）との関連が注目されるようになった。日本においてはジカ熱の流行は確認されていないものの，海外渡航からの帰国後に発症した患者が報告されている。ジカ熱に関連したGBSは脱髄型の病型を呈する場合が多く，治療は一般的なGBSに準じて行われている。発症の誘因となる自己抗体が明らかになっておらず，病態に関しては今後の研究課題である。

参考文献

1)Gould EA, Solomon T: Pathogenic flaviviruses. Lancet 371: 500-509, 2008

2)Petersen LR, Jamieson DJ, Powers AM, Honein MA: Zika virus. N Engl J Med 374: 1552-1563, 2016

3)忽那賢志, 加藤康幸: わが国における最初のジカウイルス感染症患者3例の報告. ウイルス66: 75-78, 2016

4)Araujo AQ, Silva MT, Araujo AP: Zika virus-associated neurological disorders: a review. Brain 139: 2122-2130, 2016

5)Relich RF, Loeffelholz M: Zika virus. Clin Lab Med 37: 253-267, 2017

6)Zhang Q, Sun K, Chinazzi M, Pastore Y, Piontti A, et al: Spread of Zika virus in the Americas. Proc Natl Acad Sci U S A 114: E4334-E4343, 2017

7)Massad E, Tan SH, Khan K, Wilder-Smith A: Estimated Zika virus importations to Europe by travellers from Brazil. Glob Health Action 9: 31669, 2016［doi: 10.3402/gha.v9.31669］

8)Kutsuna S, Kato Y, Takasaki T, Moi M, Kotaki A, et al: Two cases of Zika fever imported from French Polynesia to Japan, December 2013 to January 2014. Euro Surveill 19: pii: 20683, 2014

9)Rozé B, Najioullah F, Fergé JL, Apetse K, Brouste Y, et al: Zika virus detection in urine from patients with Guillain-Barré syndrome on Martinique, January 2016. Euro Surveill 21: 30154, 2016［doi: 10.2807/1560-7917.ES.2016.21.9.30154］

10)Barzon L, Pacenti M, Berto A, Sinigaglia A, Franchin E, et al: Isolation of infectious Zika virus from saliva and prolonged viral RNA shedding in a traveller returning from the Dominican Republic to Italy, January 2016. Euro Surveill 21: 30159, 2016［doi: 10.2807/1560-7917.ES.2016.21.10.30159］

11)Kutsuna S: Zika virus infection: clinical overview with a summary of Japanese cases. Clin Exp Neuroimmunol 8: 192-198, 2017

12)Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, et al: Zika virus associated with microcephaly. N Engl J Med 374: 951-958, 2016

13)Mécharles S, Herrmann C, Poullain P, Tran TH, Deschamps N, et al: Acute myelitis due to Zika virus infection. Lancet 387: 1481, 2016［doi: 10.1016/S0140-6736(16)00644-9］

14)Carteaux G, Maquart M, Bedet A, Contou D, Brugières P, et al: Zika virus associated with meningoencephalitis. N Engl J Med 374: 1595-1596, 2016

15)Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, et al: Zika virus infection complicated by Guillain-Barré syndrome-case report, French Polynesia, December 2013. Euro Surveill 19: pii: 20720, 2014

16)Cao-Lormeau VM, Blake A, Mons S, Lastere S, Roche C, et al: Guillain-Barré syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 387: 1531-1539, 2016

17)Parra B, Lizarazo J, Jiménez-Arango JA, Zea-Vera AF, González-Manrique G, et al: Guillain-Barré syndrome associated with Zika virus infection in Colombia. N Engl J Med 375: 1513-1523, 2016

18)da Silva IRF, Frontera JA, Bispo de Filippis AM, Nascimento OJMD; RIO-GBS-ZIKV Research Group: Neurologic complications associated with the Zika virus in Brazilian adults. JAMA Neurol 74: 1190-1198, 2017

19)Dos Santos T, Rodriguez A, Almiron M, Sanhueza A, Ramon P, et al: Zika virus and the Guillain-Barré syndrome - case series from seven countries. N Engl J Med 375: 1598-1601, 2016

20)「ギラン・バレー症候群, フィッシャー症候群診療ガイドライン」作成委員会（編）日本神経学会（監）: ギラン・バレー症候群, フィッシャー症候群診療ガイドライン2013. 南光堂, 東京, 2013

21)Govoni V, Granieri E: Epidemiology of the Guillain-Barré syndrome. Curr Opin Neurol 14: 605-613, 2001

22)Hughes RA, Cornblath DR: Guillain-Barré syndrome. Lancet 366: 1653-1666, 2005

23)Griffin JW, Li CY, Ho TW, Xue P, Macko C, et al: Guillain-Barré syndrome in northern China. The spectrum of neuropathological changes in clinically defined cases. Brain 118: 577-595, 1995

24)Kuwabara S, Yuki N: Axonal Guillain-Barré syndrome: concepts and controversies. Lancet Neurol 12: 1180-1188, 2013

25)Koga M, Gilbert M, Li J, Koike S, Takahashi M, et al: Antecedent infections in Fisher syndrome: a common pathogenesis of molecular mimicry. Neurology 64: 1605-1611, 2005

26)Mori M, Kuwabara S, Miyake M, Noda M, Kuroki H, et al: Haemophilus influenzae infection and Guillain-Barré syndrome. Brain 123: 2171-2178, 2000

27)Kaida K, Kusunoki S, Kamakura K, Motoyoshi K, Kanazawa I: Guillain-Barré syndrome with IgM antibody to the ganglioside GalNAc-GD1a. J Neuroimmunol 113: 260-267, 2001

28)Brasil P, Sequeira PC, Freitas AD, Zogbi HE, Calvet GA, et al: Guillain-Barré syndrome associated with Zika virus infection. Lancet 387: 1482, 2016

29)Araujo LM, Ferreira ML, Nascimento OJ: Guillain-Barré syndrome associated with the Zika virus outbreak in Brazil. Arq Neuropsiquiatr 74: 253-255, 2016

30)do Rosário MS, de Jesus PA, Vasilakis N, Farias DS, Novaes MA, et al: Guillain-Barré syndrome after Zika virus infection in Brazil. Am J Trop Med Hyg 95: 1157-1160, 2016

31)Malta JM, Vargas A, Leite PL, Percio J, Coelho GE, et al: Guillain-Barré syndrome and other neurological manifestations possibly related to Zika virus infection in municipalities from Bahia, Brazil, 2015. Epidemiol Serv Saude 26: 9-18, 2017

32)Arias A, Torres-Tobar L, Hernández G, Paipilla D, Palacios E, et al: Guillain-Barré syndrome in patients with a recent history of Zika in Cúcuta, Colombia: a descriptive case series of 19 patients from December 2015 to March 2016. J Crit Care 37: 19-23, 2017

33)Boggild AK, Geduld J, Libman M, Yansouni CP, McCarthy AE, et al: Surveillance report of Zika virus among Canadian travellers returning from the Americas. CMAJ 189: E334-E340, 2017［doi: 10.1503/cmaj.161241］

34)Anaya JM, Rodríguez Y, Monsalve DM, Vega D, Ojeda E, et al: A comprehensive analysis and immunobiology of autoimmune neurological syndromes during the Zika virus outbreak in Cúcuta, Colombia. J Autoimmun 77: 123-138, 2017

35)Journel I, Andrécy LL, Metellus D, Pierre JS, Faublas RM, et al: Transmission of Zika virus - Haiti, October 12, 2015-September 10, 2016. MMWR Morb Mortal Wkly Rep 66: 172-176, 2017

36)Sebastián UU, Ricardo AVA, Alvarez BC, Cubides A, Luna AF, et al: Zika virus-induced neurological critical illness in Latin America: Severe Guillain-Barre syndrome and encephalitis. J Crit Care 42: 275-281, 2017

37)Dirlikov E, Major CG, Mayshack M, Medina N, Matos D, et al: Guillain-Barré syndrome during ongoing Zika virus transmission - Puerto Rico, January 1-July 31, 2016. MMWR Morb Mortal Wkly Rep 65: 910-914, 2016

38)Fabrizius RG, Anderson K, Hendel-Paterson B, Kaiser RM, Maalim S, et al: Guillain-Barré syndrome associated with Zika virus infection in a traveler returning from Guyana. Am J Trop Med Hyg 95: 1161-1165, 2016

39)Fontes CA, Dos Santos AA, Marchiori E: Magnetic resonance imaging findings in Guillain-Barré syndrome caused by Zika virus infection. Neuroradiology 58: 837-838, 2016

40)Langerak T, Yang H, Baptista M, Doornekamp L, Kerkman T, et al: Zika virus infection and Guillain-Barré syndrome in three patients from Suriname. Front Neurol 7: 233, 2016［doi: 10.3389/fneur.2016.00233］

41)Siu R, Bukhari W, Todd A, Gunn W, Huang QS, et al: Acute Zika infection with concurrent onset of Guillain-Barré syndrome. Neurology 87: 1623-1624, 2016

42)Villamil-Gomez WE, Sánchez-Herrera ÁR, Hernandez H, Hernández-Iriarte J, Díaz-Ricardo K, et al: Guillain-Barré syndrome during the Zika virus outbreak in Sucre, Colombia, 2016. Travel Med Infect Dis 16: 62-63, 2017

43)Miller E, Becker Z, Shalev D, Lee CT, Cioroiu C, et al: Probable Zika virus-associated Guillain-Barré syndrome: challenges with clinico-laboratory diagnosis. J Neurol Sci 375: 367-370, 2017

44)Nascimento OJM, da Silva IRF: Guillain-Barré syndrome and Zika virus outbreaks. Curr Opin Neurol 30: 500-507, 2017

45)Kusunoki S, Hitoshi S, Kaida K, Arita M, Kanazawa I: Monospecific anti-GD1b IgG is required to induce rabbit ataxic neuropathy. Ann Neurol 45: 400-403, 1999

46)Kaida K, Morita D, Kanzaki M, Kamakura K, Motoyoshi K, et al: Ganglioside complexes as new target antigens in Guillain-Barré syndrome. Ann Neurol 56: 567-571, 2004

47)Yuki N, Hartung HP: Guillain-Barré syndrome. N Engl J Med 366: 2294-2304, 2012

48)Hafer-Macko C, Hsieh ST, Li CY, Ho TW, Sheikh K, et al: Acute motor axonal neuropathy: an antibody-mediated attack on axolemma. Ann Neurol 40: 635-644, 1996

49)Asbury AK, Arnason BG, Adams RD: The inflammatory lesion in idiopathic polyneuritis. Its role in pathogenesis. Medicine (Baltimore) 48: 173-215, 1969

50)Prineas JW: Acute idiopathic polyneuritis. An electron microscope study. Lab Invest 26: 133-147, 1972

51)Hafer-Macko CE, Sheikh KA, Li CY, Ho TW, Cornblath DR, et al: Immune attack on the Schwann cell surface in acute inflammatory demyelinating polyneuropathy. Ann Neurol 39: 625-635, 1996

52)Sawai S, Satoh M, Mori M, Misawa S, Sogawa K, et al: Moesin is a possible target molecule for cytomegalovirus-related Guillain-Barré syndrome. Neurology 83: 113-117, 2014

53)Koike H, Atsuta N, Adachi H, Iijima M, Katsuno M, et al: Clinicopathological features of acute autonomic and sensory neuropathy. Brain 133: 2881-2896, 2010

54)Koike H, Watanabe H, Sobue G: The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. J Neurol Neurosurg Psychiatry 84: 98-106, 2013

55)Nascimento OJM, Frontera JA, Amitrano DA, Bispo de Filippis AM, Da Silva IRF, et al: Zika virus infection-associated acute transient polyneuritis. Neurology 88: 2330-2332, 2017

56)Lucchese G, Kanduc D: Zika virus and autoimmunity: from microcephaly to Guillain-Barré syndrome, and beyond. Autoimmun Rev 15: 801-808, 2016

57)Lucchese G, Kanduc D: Minimal immune determinants connect Zika virus, human Cytomegalovirus, and Toxoplasma gondii to microcephaly-related human proteins. Am J Reprod Immunol 77: e12068, 2017［doi: 10.1111/aji.12608］