BRAIN and NERVE－神経研究の進歩70巻2号

2018年02月発行

特集 知っておきたい神経感染症

エンテロウイルスによる手足口病と脳炎，髄膜炎

著者： 藤本嗣人¹

所属機関： ¹国立感染症研究所感染症疫学センター第四室

ページ範囲：P.121 - P.131

文献概要

エンテロウイルスA71型（EV-A71），コクサッキーウイルスA群16型（CV-A16）および近年はCV-A6が手足口病の主要な起因病原体である。これらはすべてピコルナウイルス科，エンテロウイルス属，Enterovirus A種に属し，時に無菌性髄膜炎および脳炎および麻痺を引き起こす。東アジア，東南アジアは1997〜2013年に大きなEV-A71のアウトブレイクを経験し，その間に致死例を含む重篤な脳炎症例を経験した。本論文では手足口病に関連した，中枢神経系感染症，疫学，臨床症状および治療，および手足口病研究の歴史をまとめた。重症EV-A71感染症の予防，重症度分類，診断，検体採取法，および治療に関して概説した。

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